ArticleEnvironmental health perspectives2024
Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet-Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis.
Article in Environmental health perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Colonic Barrier Dysfunction and Inflammation Induced by Nano-/Micro-Plastics Fibers in Mice via the FAK/NF-κB/iNOS and TLR4/NF-κB/iNOS Pathways.Journal of applied toxicology : JAT · 2026Article
- Microplastics and Nanoplastics in Food: Dietary Toxicology Beyond Particle Counts.Comprehensive reviews in food science and food safety · 2026Review
- Microplastics in early-onset carcinogenesis.Carcinogenesis · 2026Review
- Microplastics as Vectors Influencing Oxidative Stress, Inflammation, and Endocrine Function During Early Development.International journal of molecular sciences · 2026Review
- Micro- and Nanoplastics as Disruptors of Digestive and Hepatopancreatic Homeostasis: Insights into the Plastic-Gut-Liver Axis.International journal of molecular sciences · 2026Review
- 1,1-Diethoxyethane increases insulin sensitivity and ameliorates obesity and dyslipidemia in mice fed high-fat diet.npj metabolic health and disease · 2026Article
- Hyodeoxycholic acid ameliorates tacrolimus-induced diabetes by modulating the FXR-FGF15 axis.Frontiers in pharmacology · 2026Article
- Chronic PET-Microplastic Exposure: Disruption of Gut-Liver Homeostasis and Risk of Hepatic Steatosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health.World journal of hepatology · 2025Review
- Fucoidan Therapy for Extraintestinal Diseases: Targeting the Microbiota-Gut-Organ Axes.Biomolecules · 2025Review
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- Microplastics' Impact on the Development of AOM/DSS-Induced Colitis-Associated Colorectal Cancer in Mice.International journal of molecular sciences · 2025Article
- Diesel exhaust induces gut microbiome dysbiosis and reduced fecal acetate: Role of acetate supplementation.Ecotoxicology and environmental safety · 2025Article
- Polystyrene Accelerates Aging Related-Gut Microbiome Dysbiosis and -Metabolites in Old-Aged Mouse.Journal of microbiology and biotechnology · 2025Article
- Acupuncture as A Potential Therapeutic Approach for Tourette Syndrome: Modulation of Neurotransmitter Levels and Gut Microbiota.Chinese journal of integrative medicine · 2025Article
- Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics.Apoptosis : an international journal on programmed cell death · 2025Article
- Gut Microbiota-Targeted Intervention of Hyperlipidemia UsingPharmaceuticals (Basel, Switzerland) · 2025Article
- Neohesperidin Mitigates High-Fat-Diet-Induced Colitis In Vivo by Modulating Gut Microbiota and Enhancing SCFAs Synthesis.International journal of molecular sciences · 2025Article
- Artificial plasticenta: how polystyrene nanoplastics affectFrontiers in cell and developmental biology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroplastics (MPs) have become a global environmental problem, emerging as contaminants with potentially alarming consequences. However, long-term exposure to polystyrene microspheres (PS-MS) and its effects on diet-induced obesity are not yet fully understood.
objectivesWe aimed to investigate the effect of PS-MS exposure on high-fat diet (HFD)-induced obesity and underlying mechanisms.
methodsIn the present study, C57BL/6J mice were fed a normal diet (ND) or a HFD in the absence or presence of PS-MS via oral administration for 8 wk. Antibiotic depletion of the microbiota and fecal microbiota transplantation (FMT) were performed to assess the influence of PS-MS on intestinal microbial ecology. We performed 16S rRNA sequencing to dissect microbial discrepancies and investigated the dysbiosis-associated intestinal integrity and inflammation in serum.
resultsCompared with HFD mice, mice fed the HFD with PS-MS exhibited higher body weight, liver weight, metabolic dysfunction-associated steatotic liver disease (MASLD) activity scores, and mass of white adipose tissue, as well as higher blood glucose and serum lipid concentrations. Furthermore, 16S rRNA sequencing of the fecal microbiota revealed that mice fed the HFD with PS-MS had greater
conclusionsOur findings provide a new gut microbiota-driven mechanism for PS-MS-induced obesity in HFD-fed mice, suggesting the need to reevaluate the adverse health effects of MPs commonly found in daily life, particularly in susceptible populations. https://doi.org/10.1289/EHP13913.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.