Evidence map›Paper›PMID 39227159›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Role of the STING→IRF3 Pathway in Ambient GABA Homeostasis and Cognitive Function.

Chiranjivi Neupane, Ramesh Sharma, Fei Fei Gao, Thuy Linh Pham, Yoo Sung Kim, Bo-Eun Yoon, Eun-Kyeong Jo, Kyung-Cheol Sohn, Gang Min Hur, Guang-Ho Cha and 3 more

Erratum issuedAbstract read
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In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Chiranjivi NeupaneLaboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08823, Korea.ORCID 0000-0003-2719-9331
Ramesh SharmaLaboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08823, Korea.ORCID 0000-0002-8563-6109
Fei Fei GaoDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Thuy Linh PhamDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Yoo Sung KimDepartment of Molecular Biology, Dankook University, Cheonan 31116, Korea.
Bo-Eun YoonDepartment of Molecular Biology, Dankook University, Cheonan 31116, Korea.ORCID 0000-0002-1506-2437
Eun-Kyeong JoDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Kyung-Cheol SohnPharmacology, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Gang Min HurDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Guang-Ho ChaDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Sun Seek MinDepartment of Physiology, Eulji University School of Medicine, Daejeon 35233, Korea.
Cuk-Seong KimDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Jin Bong ParkLaboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08823, Korea jbpark@snu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting altered expression and/or activity of GABA (γ-aminobutyric acid) transporters (GATs) provide therapeutic benefit for age-related impairments, including cognitive dysfunction. However, the mechanisms underlying the transcriptional regulation of GATs are unknown. In the present study, we demonstrated that the stimulator of interferon genes (STING) upregulates GAT1 and GAT3 expression in the brain, which resulted in cognitive dysfunction. Genetic and pharmacological intervention of STING suppressed the expression of both GAT1 and GAT3, increased the ambient GABA concentration, and therefore, enhanced tonic GABA

Indexed as

GABA Plasma Membrane Transport Proteinsgamma-Aminobutyric AcidHomeostasisInterferon Regulatory Factor-3Membrane ProteinsMice, Inbred C57BLSignal TransductionAnimalsCognitionHippocampusMaleMiceMice, KnockoutSTING ProteinGABA Plasma Membrane Transport Proteinsgamma-Aminobutyric AcidInterferon Regulatory Factor-3Irf3 protein, mouseMembrane ProteinsSlc6a1 protein, mouseSting1 protein, mouseSTING ProteinGATsmemorySTING→IRF3tonic GABA

Identifiers

PMID39227159
PMCPMC11466066

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.