Evidence map›Paper›PMID 39227944›Full record

ArticleJournal of nanobiotechnology2024

Tumor microenvironment-responsive manganese-based nano-modulator activate the cGAS-STING pathway to enhance innate immune system response.

Xiayi Liang, Duo Wang, Yuanquan Zhao, Xiaobo Wang, Siyang Yao, Wei Huang, Yongyu Yang, Xiaofeng Dong, Lei Zhang, Jianrong Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Immunomodulatory Nanozymes as Programmable Redox-Immune Set-Point Regulators.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. CaMaterials today. Bio · 2026
    Article
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  19. Embracing cancer immunotherapy with manganese particles.Cellular oncology (Dordrecht, Netherlands) · 2025
    Review
  20. Sericin-coated MnOScientific reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiayi Liang *Department of Hepatobiliary Surgery, Department of Medical Ultrasound, Tumor Hospital of Guangxi Medical University, Guangxi Medical University, No. 71 Hedi Road, Nanning, 530021, Guangxi, China.
Duo Wang *Center of Interventional Radiology & Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 224001, China.
Yuanquan Zhao *Department of Hepatobiliary, Pancreas and Spleen Surgery, the People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530021, China.
Xiaobo WangDepartment of Hepatobiliary Surgery, Department of Medical Ultrasound, Tumor Hospital of Guangxi Medical University, Guangxi Medical University, No. 71 Hedi Road, Nanning, 530021, Guangxi, China.
Siyang YaoDepartment of Hepatobiliary, Pancreas and Spleen Surgery, the People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530021, China.
Wei HuangDepartment of Hepatobiliary, Pancreas and Spleen Surgery, the People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530021, China.
Yongyu YangDepartment of Hepatobiliary, Pancreas and Spleen Surgery, the People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530021, China.
Xiaofeng DongDepartment of Hepatobiliary, Pancreas and Spleen Surgery, the People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530021, China. gandanyingcai@163.com.
Lei ZhangCenter of Interventional Radiology & Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 224001, China. zhang_lei@seu.edu.cn.
Jianrong YangDepartment of Hepatobiliary, Pancreas and Spleen Surgery, the People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530021, China. gandansurgery2014@163.com.

Funding

National Natural Science Foundation of China No. 82160589National Natural Science Foundation of China No. 82302330National Natural Science Foundation of China No. 82360569Postdoctoral Fellowship Program of CPSF BX20230068Research Personnel Cultivation Programme of Zhongda Hospital Southeast University CZXM-GSP-RC81Science and Technology Major Project of Guangxi GuikeAA23073013
6 · The paper itself

Abstract

backgroundManganese ions (Mn

conclusionsThis HA-modified manganese-based hybrid nano-regulator can enhance antitumor therapy by boosting innate immune activity and may provide new directions for immunotherapy and clinical translation in cancer.

Indexed as

Immunity, InnateManganese CompoundsMembrane ProteinsNucleotidyltransferasesOxidesSignal TransductionTumor MicroenvironmentAnimalsAntineoplastic AgentsCell Line, TumorCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseFemaleHumansManganeseMiceMice, Inbred C57BLAntineoplastic AgentscGAS protein, humancGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseManganeseManganese Compoundsmanganese dioxideMembrane ProteinsNucleotidyltransferasesOxidesReactive Oxygen SpeciesSTING1 protein, humanSting1 protein, mouseSTING ProteincGAS-STING pathwayInnate immunityManganese immunotherapyTumor microenvironment

Identifiers

PMID39227944
PMCPMC11373498

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.