Evidence map›Paper›PMID 39229019›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular Visualization of Neuronal TDP43 Pathology

Amanda L Erwin, Martin G Fernandez, Matthew L Chang, Durga Attili, Michael Bekier, Emile S Pinarbasi, Jennifer E Russ, Renaldo Sutanto, Dafydd Thomas, Xinfei Shen and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amanda L ErwinLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, United States.
Martin G FernandezLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, United States.
Matthew L ChangLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, United States.
Durga AttiliLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, United States.
Michael BekierDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109, United States.
Emile S PinarbasiDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109, United States.
Jennifer E RussDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, United States.
Renaldo SutantoLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, United States.
Dafydd ThomasDepartment of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, United States.
Xinfei ShenDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, United States.
Ryan D BaldridgeDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, United States.ORCID 0000-0001-7158-7812
Elizabeth M H TankDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109, United States.
Sami J BarmadaDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109, United States.ORCID 0000-0002-9604-968X
Shyamal MosalagantiLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, United States.ORCID 0000-0002-5934-687X

Funding

Research Education ComponentP30AG072931 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREW P LIEBERMAN · 2021 to 2026
$26.5M
PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
RNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degenerationR01NS097542 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2016 to 2025
$3.8M
Protein quality control at eukaryotic membranes.R35GM128592 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ryan Douglas Baldridge · 2018 to 2026
$3.3M
In-situ architecture of membrane contact sites mediating organelle fissionDP2GM150019 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOSALAGANTI, SHYAMAL · 2022 to 2025
$2.3M
Training Program in Translational ResearchT32GM141840 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREW P LIEBERMAN, Zaneta Nikolovska-Coleska · 2021 to 2026
$2.0M
Atypical TDP43 isoforrms driving neurodegeneration in FTD/ALSR01NS113943 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2020 to 2024
$1.9M
Regulation and impact of shortened TDP43 isoforms in FTD and ALSR37NS113943 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2025 to 2025
$1.8M
Compute Cluster for in vitro and in situ Analysis of Molecular MachinesS10OD030275 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OHI, MELANIE DIANE · 2021 to 2021
$600k
Spatiotemporal analysis of TDP-43 toxicity and endolysosomal turnover mechanismsR56NS128110 · NINDS · UNIVERSITY OF ARIZONA · PI BARMADA, SAMI, BUCHAN, JOHN ROSS · 2022 to 2022
$393k
Identifying the function of alternatively spliced TDP43 isoforms and contribution to diseaseF31NS134123 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DYKSTRA, MEGAN · 2023 to 2024
$83k
NIA NIH HHS P30 AG072931NIGMS NIH HHS DP2 GM150019NIGMS NIH HHS R35 GM128592NIGMS NIH HHS T32 GM007544NIGMS NIH HHS T32 GM141840NIH HHS S10 OD030275NINDS NIH HHS F31 NS134123NINDS NIH HHS R01 NS097542NINDS NIH HHS R01 NS113943NINDS NIH HHS R37 NS113943NINDS NIH HHS R56 NS128110
6 · The paper itself

Abstract

Nuclear exclusion and cytoplasmic accumulation of the RNA-binding protein TDP43 are characteristic of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Despite this, the origin and ultrastructure of cytosolic TDP43 deposits remain unknown. Accumulating evidence suggests that abnormal RNA homeostasis can drive pathological TDP43 mislocalization, thereby enhancing RNA misprocessing due to the loss of nuclear TDP43, and engendering a cycle that ultimately leads to cell death. Here, we demonstrate that the addition of small monovalent oligonucleotides successfully recapitulates pathological TDP43 mislocalization and aggregation, aberrant splicing, and degeneration in iPSC-derived neurons (iNeurons). By employing a tailored multimodal

Identifiers

PMID39229019
PMCPMC11370468

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.