Evidence map›Paper›PMID 39229067›Full record

ArticlebioRxiv : the preprint server for biology2024

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening.

Jasmin C Aschenbrenner, Andre Schutzer de Godoy, Michael Fairhead, Charles W E Tomlinson, Max Winokan, Blake H Balcomb, Eda Capkin, Anu V Chandran, Mathew Golding, Lizbe Koekemoer and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jasmin C AschenbrennerDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0002-4318-0481
Andre Schutzer de GodoySão Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.ORCID 0000-0002-0613-9164
Michael FairheadCentre for Medicines Discovery, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-5361-3933
Charles W E TomlinsonDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0002-1845-6028
Max WinokanDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0002-1318-4422
Blake H BalcombDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0001-7599-8467
Eda CapkinDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0003-4570-6683
Anu V ChandranDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0001-9942-2614
Mathew GoldingDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0009-0004-7472-8333
Lizbe KoekemoerCentre for Medicines Discovery, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-9226-9127
Ryan M LithgoDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0002-4706-9916
Peter G MarplesDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0002-8787-7969
Xiaomin NiCentre for Medicines Discovery, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-7769-8297
Warren ThompsonDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0003-1474-7810
Conor WildDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0003-0654-8141
Mary-Ann E XavierDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0001-9672-0763
Daren FearonDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0003-3529-7863
Frank von DelftDiamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.ORCID 0000-0003-0378-0017

Funding

Research Project 1: Coronavirus antiviral lead development and combination testingU19AI171292 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, WILLSON, TIMOTHY M · 2022 to 2022
$65.5M
NIAID NIH HHS U19 AI171292
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for months

Identifiers

PMID39229067
PMCPMC11370605

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.