Evidence map›Paper›PMID 39229119›Full record

ArticlebioRxiv : the preprint server for biology2024

Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production.

Kleiton S Borges, Donald W Little, Taciani de Almeida Magalhães, Claudio Ribeiro, Typhanie Dumontet, Chris Lapensee, Kaitlin J Basham, Aishwarya Seth, Svetlana Azova, Nick A Guagliardo and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kleiton S BorgesDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0003-0356-922X
Donald W LittleDoctoral Program in Cancer Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
Taciani de Almeida MagalhãesDepartment of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA.
Claudio RibeiroDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.
Typhanie DumontetDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, 48109, USA.
Chris LapenseeDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, 48109, USA.
Kaitlin J BashamDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.
Aishwarya SethDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.
Svetlana AzovaDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.
Nick A GuagliardoDepartment of Pharmacology, University of Virginia, Charlottesville, VA, 22908-0735, USA.
Paula Q BarrettDepartment of Pharmacology, University of Virginia, Charlottesville, VA, 22908-0735, USA.
Mesut BerberDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.
Amy E O'ConnellDepartment of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.
Adina F TurcuDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, 48109, USA.
Antonio Marcondes LerarioDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, 48109, USA.
Dipika R MohanDoctoral Program in Cancer Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
William RaineyDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, 48109, USA.
Diana L CarloneDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0001-6935-0189
Joel N HirschhornDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.
Adrian SalicDepartment of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA.
David T BreaultDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.
Gary D HammerDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, 48109, USA.

Funding

Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)K12DK133995 · NIDDK · STANFORD UNIVERSITY · PI LINDA A DIMEGLIO, David Matthew Maahs · 2022 to 2026
$16.0M
Mechanisms of Adrenal DifferentiationR01DK062027 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARY D. HAMMER · 2004 to 2026
$8.0M
Rosettes in Adrenal Development, Maintenance and DiseaseR01DK123694 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI David T Breault · 2019 to 2026
$5.6M
Primary Aldosteronism Subtypes: Pathophysiology and Steroid SignaturesR01HL155834 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TURCU, ADINA F · 2021 to 2025
$3.5M
Sending and receiving Hedgehog signalsR01GM122920 · NIGMS · HARVARD MEDICAL SCHOOL · PI SALIC, ADRIAN · 2018 to 2023
$2.7M
Sending and transducing Hedgehog and Wnt signalsR35GM153357 · NIGMS · HARVARD MEDICAL SCHOOL · PI ADRIAN SALIC · 2024 to 2026
$2.2M
The Role of Wnt2b in Intestinal HealthK08DK120871 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI OCONNELL, AMY E · 2020 to 2024
$896k
NHLBI NIH HHS R01 HL155834NIDDK NIH HHS K08 DK120871NIDDK NIH HHS K12 DK133995NIDDK NIH HHS R01 DK062027NIDDK NIH HHS R01 DK123694NIGMS NIH HHS R01 GM122920NIGMS NIH HHS R35 GM153357
6 · The paper itself

Abstract

The steroid hormone aldosterone, produced by the zona glomerulosa (zG) of the adrenal gland, is a master regulator of plasma electrolytes and blood pressure. While aldosterone control by the renin-angiotensin system is well understood, other key regulatory factors have remained elusive. Here, we replicated a prior association between a non-coding variant in

Indexed as

adrenal cortexbeta-catenin-independent signalingFamilial Hyperreninemic Hypoaldosteronismhypoaldosteronismnon-canonical Wnt signalingprimary aldosteronismrosetteWNT2BWnt/PCP pathwayzona glomerulosa

Identifiers

PMID39229119
PMCPMC11370552

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.