Evidence map›Paper›PMID 39229120›Full record

ArticlebioRxiv : the preprint server for biology2024

Protection of the Telomeric Junction by the Shelterin Complex.

Sajad Shiekh, Darion Feldt, Amanda Jack, Sineth G Kodikara, Janan Alfehaid, Sabaha Pasha, Ahmet Yildiz, Hamza Balci

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sajad ShiekhDepartment of Physics, Kent State University, Kent, OH 44242, USA.
Darion FeldtDepartment of Physics, Kent State University, Kent, OH 44242, USA.
Amanda JackBiophysics Graduate Group, University of California, Berkeley, CA 94720, USA.ORCID 0000-0001-8709-1432
Sineth G KodikaraDepartment of Physics, Kent State University, Kent, OH 44242, USA.
Janan AlfehaidDepartment of Physics, Kent State University, Kent, OH 44242, USA.
Sabaha PashaDepartment of Physics, Kent State University, Kent, OH 44242, USA.
Ahmet YildizBiophysics Graduate Group, University of California, Berkeley, CA 94720, USA.
Hamza BalciDepartment of Physics, Kent State University, Kent, OH 44242, USA.

Funding

The Mechanism and Regulation of the Dynein Transport MachineryR35GM136414 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ahmet Yildiz · 2020 to 2026
$5.1M
Targeting Promoter G-quadruplexes with CRISPR-dCas9 for Transcription RegulationR15GM146180 · NIGMS · KENT STATE UNIVERSITY · PI BALCI, HAMZA · 2022 to 2023
$539k
Influence of small molecules on G-quadruplex stability, folding kinetics, and interactions with proteinsR15GM123443 · NIGMS · KENT STATE UNIVERSITY · PI BALCI, HAMZA · 2018 to 2018
$438k
NIGMS NIH HHS R15 GM123443NIGMS NIH HHS R15 GM146180NIGMS NIH HHS R35 GM136414
6 · The paper itself

Abstract

Shelterin serves critical roles in suppressing superfluous DNA damage repair pathways on telomeres. The junction between double-stranded telomeric tracts (dsTEL) and single-stranded telomeric overhang (ssTEL) is the most accessible region of the telomeric DNA. The shelterin complex contains dsTEL and ssTEL binding proteins and can protect this junction by bridging between the ssTEL and dsTEL tracts. To test this possibility, we monitored shelterin binding to telomeric DNA substrates with varying ssTEL and dsTEL lengths and quantified its impact on telomere accessibility using single-molecule fluorescence microscopy methods

Indexed as

FRETFRET-PAINTPOT1ShelterinTelomere

Identifiers

PMID39229120
PMCPMC11370466

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.