Evidence map›Paper›PMID 39229212›Full record

ArticlebioRxiv : the preprint server for biology2024

Variant-to-function mapping of late-onset Alzheimer's disease GWAS signals in human microglial cell models implicates

Elizabeth A Burton, Mariana Argenziano, Kieona Cook, Molly Ridler, Sumei Lu, Chun Su, Elisabetta Manduchi, Sheridan H Littleton, Michelle E Leonard, Kenyaita M Hodge and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Elizabeth A BurtonCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-8376-9282
Mariana ArgenzianoCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kieona CookCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Molly RidlerCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sumei LuCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Chun SuCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Elisabetta ManduchiCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sheridan H LittletonCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-4322-4069
Michelle E LeonardCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kenyaita M HodgeEmory University, Atlanta, GA, USA.
Li-San WangDepartment of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3684-0031
Gerard D SchellenbergDepartment of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1115-2475
Matthew E JohnsonCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Matthew C PahlCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
James A PippinCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Andrew D WellsCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Stewart A AndersonDepartment of Child and Adolescent Psychiatry and Behavioral Services, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Christopher D BrownDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Struan F A GrantCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-2025-5302
Alessandra ChesiCenter for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-0954-7446

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
Variant to gene mapping for Alzheimer's DiseaseR01AG057516 · NIA · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2017 to 2021
$3.5M
Variant-to-gene mapping for brain related traits and disordersR35HG011959 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI CHESI, ALESSANDRA · 2021 to 2025
$2.4M
Implicating novel microglial mechanisms of late-onset Alzheimer's disease with variant-to-gene mapping methodsF31AG074532 · NIA · UNIVERSITY OF PENNSYLVANIA · PI BURTON, ELIZABETH ANNE · 2021 to 2023
$128k
NHGRI NIH HHS R35 HG011959NIA NIH HHS F31 AG074532NIA NIH HHS R01 AG057516NIGMS NIH HHS T32 GM008216
6 · The paper itself

Abstract

Late-onset Alzheimer's disease (LOAD) research has principally focused on neurons over the years due to their known role in the production of amyloid beta plaques and neurofibrillary tangles. In contrast, recent genomic studies of LOAD have implicated microglia as culprits of the prolonged inflammation exacerbating the neurodegeneration observed in patient brains. Indeed, recent LOAD genome-wide association studies (GWAS) have reported multiple loci near genes related to microglial function, including

Identifiers

PMID39229212
PMCPMC11370593

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.