Evidence map›Paper›PMID 39230365›Full record

ArticleThe Analyst2024

Parahydrogen-enhanced pH measurements using [1-

Maria Daniela Santi, Theresa Luca Katrin Hune, Gonzalo Gabriel Rodriguez, Lisa M Fries, Ruhuai Mei, Sonja Sternkopf, Josef Elsaßer, Stefan Glöggler

Abstract read
In one paragraph

Article in The Analyst, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Deuterated pH Probes Based on Ketoglutarate for Magnetic Resonance.Journal of the American Chemical Society · 2026
    Article
  3. BiologicalSmall science · 2025
    Article
  4. Scalable Hyperpolarized MRI Enabled by Ace-SABRE of [1-Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Daniela SantiNMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany. stefan.gloeggler@mpinat.mpg.de.ORCID http://orcid.org/0000-0002-3866-1424
Theresa Luca Katrin HuneNMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany. stefan.gloeggler@mpinat.mpg.de.
Gonzalo Gabriel RodriguezNMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany. stefan.gloeggler@mpinat.mpg.de.
Lisa M FriesNMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany. stefan.gloeggler@mpinat.mpg.de.
Ruhuai MeiNMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany. stefan.gloeggler@mpinat.mpg.de.ORCID http://orcid.org/0000-0001-7866-231X
Sonja SternkopfNMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany. stefan.gloeggler@mpinat.mpg.de.
Josef ElsaßerNMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany. stefan.gloeggler@mpinat.mpg.de.
Stefan GlögglerNMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany. stefan.gloeggler@mpinat.mpg.de.ORCID http://orcid.org/0000-0003-3354-6141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in pH are a hallmark in several pathologies including cancer, ischemia, and inflammation. Non-invasive magnetic resonance methods to measure pH offer a new approach for early diagnosis of diseases characterized by acid-base imbalances. The hyperpolarization with parahydrogen-induced polarization (PHIP) enhances inherently low signals in magnetic resonance experiments by several orders of magnitude and offers a suitable platform to obtain biocompatible markers in less than one minute. Here, we present an optimized preparation of an hyperpolarized H

Indexed as

BicarbonatesCarbon IsotopesDecarboxylationHumansHydrogenHydrogen-Ion ConcentrationHydrogen PeroxidePyruvic AcidBicarbonatesCarbon IsotopesHydrogenHydrogen PeroxidePyruvic Acid

Identifiers

PMID39230365
PMCPMC11373534

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.