Evidence map›Paper›PMID 39230629›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Perspective on oral medication adherence among patients with acute graft-versus-host disease: a qualitative descriptive study.

Chiara Visintini, Chiara Lucchetta, Margherita Venturini, Irene Mansutti, Stefania Chiappinotto, Francesca Patriarca, Alvisa Palese

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chiara VisintiniDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Montpellier's Street, 1, 00133, Rome, Italy. chiara.visintini@students.uniroma2.eu.
Chiara LucchettaOncology Unit, Udine University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Margherita VenturiniDepartment of Medicine, University of Udine, Udine, Italy.
Irene MansuttiDepartment of Medicine, University of Udine, Udine, Italy.
Stefania ChiappinottoDepartment of Medicine, University of Udine, Udine, Italy.
Francesca PatriarcaHaematology and Stem Cell Transplantation Unit, Udine University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Alvisa PaleseDepartment of Medicine, University of Udine, Udine, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDespite the importance of adherence to immunosuppressants (IMMs) after an allogeneic haematopoietic stem cell transplant (HSCT) for the treatment of acute graft-versus-host disease (aGvHD), no studies to date have reported the experiences of such patients concerning medication adherence (MA). Therefore, the aim of the study was to explore the perspective on MA to immunosuppressive oral therapy among allogeneic HSCT patients with aGvHD.

methodsA qualitative descriptive study following a reflexive thematic analysis methodological approach was performed involving a purposive sample of 16 patients with aGvHD who were being cared for in the outpatient setting of a bone marrow transplant centre and were willing to participate. Semi-structured audio-recorded interviews were conducted, transcribed verbatim and thematically analysed; member checking was performed. COnsolidated criteria for REporting Qualitative research (COREQ) and the ESPACOMP Medication Adherence Reporting Guideline were followed.

resultsParticipants aged 25-74 years and mostly males (62.5%) were recruited for this study; 56.2% developed grade I, 37.5% grade II and 6.3% grade III aGvHD; 56.2% were receiving treatment with both cyclosporine and prednisone. Patients' perspectives have been summarised into four themes, named: "Transiting from an external obligation to a habit"; "Being in the middle between the negative and positive effects of the IMMs"; "Failure to systematically respect the rules"; and "Adopting personal strategies to become adherent". After difficulties with the perception of feeling obliged, patients became used to adhering to IMMs. Although there were failures in systematically taking the medication correctly and there were episodes of non-adherence, the adoption of personal strategies helped patients to become adherent to their medication schedules.

conclusionsMA in patients with aGvHD is a complex behaviour and is often a challenge. These results can help healthcare professionals and centres to understand how best to design tailored strategies and behavioural interventions to maximise patients' MA to IMMs.

Indexed as

Drug MonitoringGraft vs Host DiseaseHematopoietic Stem Cell TransplantationImmunosuppressive AgentsQualitative ResearchAcute DiseaseAdministration, OralAdultAgedCyclosporineFemaleHumansMaleMiddle AgedCyclosporineImmunosuppressive AgentsGraft-versus-host diseaseHaematopoietic stem cell transplantImmunosuppressantsMedication adherencePatient perspective

Identifiers

PMID39230629
PMCPMC11374915

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.