Evidence map›Paper›PMID 39230875›Full record

ArticleEuropean journal of preventive cardiology2025

Plasma levels of polyols erythritol, mannitol, and sorbitol and incident coronary heart disease among women.

Yoriko Heianza, Qi Sun, Xuan Wang, Saumya Tiwari, Jeramie D Watrous, Kathryn M Rexrode, Mona Alotaibi, Mohit Jain, Samia Mora, Walter C Willett and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Functional PET imaging of gut microbiota with [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yoriko HeianzaDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.ORCID 0000-0002-0957-9309
Qi SunDepartment of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.ORCID 0000-0002-8480-1563
Xuan WangDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.
Saumya TiwariDepartment of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Jeramie D WatrousDepartment of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Kathryn M RexrodeChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Mona AlotaibiDepartment of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Mohit JainDepartment of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Samia MoraDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.
Walter C WillettDepartment of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Lu QiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.ORCID 0000-0002-8041-7791
JoAnn E MansonDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.ORCID 0000-0002-9426-7595

Funding

RISK FACTORS FOR CVD IN WOMENR01HL034594 · TULANE UNIVERSITY OF LOUISIANA · 1985 to 2025
$3.5M
Premenopausal Hormone Levels and Risk of Breast CancerR01CA067262 · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · 2002 to 2005
$2.7M
Tulane COBRE for Clinical and Translational Research in Cardiometabolic DiseasesP20GM109036 · TULANE UNIVERSITY OF LOUISIANA · 2025 to 2025
$2.2M
Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet InterventionsR01DK115679 · TULANE UNIVERSITY OF LOUISIANA · 2025 to 2025
$656k
Patient Centered Approaches to Preventing ASCVD EventsK24HL136852 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · 2022 to 2025
$247k
NCI NIH HHS R01 CA067262NHLBI NIH HHS K24 HL136852NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R21 HL126024NIDDK NIH HHS DK091718NIDDK NIH HHS R01 DK115679NIGMS NIH HHS 2P20GM109036-06A1NIGMS NIH HHS P20 GM109036NIH HHS UM1 CA186107Tulane Research Centers of Excellence Awards
6 · The paper itself

Abstract

aimsErythritol, a sugar alcohol (polyol), has recently been linked to the risk of major adverse cardiovascular events. We investigated whether plasma erythritol and other polyols (mannitol/sorbitol) were associated with the risk of incident coronary heart disease (CHD). METHODS AND

resultsThis prospective nested case-control study included 762 incident cases of CHD and 762 controls from the Nurses' Health Study. Plasma concentrations of polyols were measured at baseline (1989-90 or 2000-02). Associations of erythritol with cardiometabolic risk factors were also analysed in the Women's Lifestyle Validation Study (n = 728; blood collected in 2010-12). Higher erythritol levels were related to more adverse cardiometabolic risk factor status. A relative risk (RR) for CHD per 1-SD increment was 1.15 [95% confidence interval (CI): 1.04, 1.28] for erythritol and 1.16 (95% CI: 1.05, 1.28) for mannitol/sorbitol, after adjusting for diet quality, lifestyles, and adiposity. Compared with women in the lowest quartile, those in the highest quartile (Q4) of erythritol had an RR of 1.55 (95% CI: 1.13, 2.14) for CHD. The RR in the Q4 of erythritol was 1.61 (95% CI: 1.15, 2.24; P = 0.006) when hypertension and dyslipidaemia were further added to the model; the RR was 1.21 (95% CI: 0.86, 1.70) after adjustment for diabetes. For mannitol/sorbitol, the RR in Q4 was 1.42 (95% CI: 1.05, 1.91; P = 0.022) for CHD in the multivariable-adjusted model including diabetes.

conclusionHigher levels of plasma erythritol and mannitol/sorbitol were related to elevated risks of CHD even after adjustment for diet, lifestyles, adiposity, and other risk factors. The unfavourable association of mannitol/sorbitol, but not of erythritol, with CHD risk remained significant independent of diabetes/hyperglycaemia.

Indexed as

Coronary DiseaseErythritolMannitolSorbitolAdultBiomarkersCase-Control StudiesFemaleHumansIncidenceMiddle AgedPolymersProspective StudiesRisk AssessmentRisk FactorsUnited StatesBiomarkersErythritolMannitolPolymerspolyolSorbitolCoronary heart diseaseErythritolProspective cohort studyRisk factorsSugar alcohols (polyols)

Identifiers

PMID39230875
PMCPMC11962730

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.