Evidence map›Paper›PMID 39231871›Full record

Trial reportEuropean journal of nutrition2024

Effects of different doses of caffeine on cognitive performance in healthy physically active individuals.

María Ramírez-delaCruz, Paula Esteban-García, Pablo Abián, Alfredo Bravo-Sánchez, Inés Piñas-Bonilla, Javier Abián-Vicén

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05995314 (Effects Of Different Doses Of Caffeine On Cognitive Performance In Healthy Physically Active Individuals), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05995314 nacompletednot on this map

Effects Of Different Doses Of Caffeine On Cognitive Performance In Healthy Physically Active Individuals

TypeinterventionalSponsorUniversity of Castilla-La ManchaRan2023 to 2023Enrolled30ConditionsCaffeineArmsPLACEBO, 3 mg/kg of caffeine, 6 mg/kg of caffeine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

María Ramírez-delaCruzPerformance and Sport Rehabilitation Laboratory (DEPORSALUD), Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.ORCID http://orcid.org/0000-0002-7898-1254
Paula Esteban-GarcíaPerformance and Sport Rehabilitation Laboratory (DEPORSALUD), Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.ORCID http://orcid.org/0000-0002-7690-9734
Pablo AbiánFaculty of Humanities and Social Sciences, Comillas Pontifical University, Calle Universidad Comillas, 3-5, Madrid, 28049, Spain.
Alfredo Bravo-SánchezFaculty of Health Sciences, Universidad Francisco de Vitoria, Ctra. Pozuelo- Majadahonda km 1,800, Pozuelo de Alarcón, 28223, Spain.ORCID http://orcid.org/0000-0002-0476-066X
Inés Piñas-BonillaFaculty of Medicine, University of Extremadura, Avda. De Elvas, s/n. 06006. Badajoz, Badajoz, Spain.
Javier Abián-VicénPerformance and Sport Rehabilitation Laboratory (DEPORSALUD), Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain. javier.abian@uclm.es.ORCID http://orcid.org/0000-0001-9635-3289

Funding

Education, Audiovisual and Culture Executive Agency 2018-3795/001-001Junta de Comunidades de Castilla-La Mancha 2020-PREDUCLM-16702
6 · The paper itself

Abstract

purposeCaffeine is a potent central nervous system stimulant that increases the activity of the prefrontal cortex and can improve various cognitive skills. An improvement in these cognitive skills can lead to further benefits in athletic performance. Therefore, it is necessary to clarify the dose-response of caffeine on cognitive performance. This study aimed to determine the effects of different doses of caffeine on sport-related cognitive aspects.

methodsTwenty-nine healthy physically active young adults were recruited. All participants completed three trials under the following conditions: (a) placebo, (b) 3 mg/kg, or (c) 6 mg/kg body mass of caffeine. In each trial, different cognitive abilities were evaluated with the following battery of tests: reaction time (Dynavision™ D2), anticipation (Bassin Anticipation Timer), sustained attention (Go/No-Go and Eriksen Flanker Test) and memory tests. Moreover, the side effects and the perceived sensation index were recorded 24 h after each test.

resultsReaction time only improved following 6 mg/kg of caffeine intake (Physical reaction time: -0.04 s, 95% CI -0.08 to -0.01 s, P = 0.036, d = 0.5; Motor reaction time: -0.04 s, 95% CI -0.07 to -0.01 s, P = 0.008, d = 0.6) compared to the placebo condition. Anticipation, sustained attention, and memory were not affected after either caffeine dose intake (all P > 0.05). In addition, the 6 mg/kg dose of caffeine augmented the occurrence of the side effects of increased activeness (P = 0.046) and nervousness (P = 0.001).

conclusionAcute intake of 6 mg/kg caffeine is effective in improving reaction time despite increasing the occurrence of side effects in healthy physically active young adults. STUDY REGISTRATION: This study has been registered in ClinicalTrials whose ID is: NCT05995314 (2023-08-08).

Indexed as

CaffeineCentral Nervous System StimulantsCognitionDose-Response Relationship, DrugReaction TimeAdultAthletic PerformanceAttentionCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMemoryYoung AdultCaffeineCentral Nervous System StimulantsAnticipationAttentionErgogenic aidMemoryReaction timeSports performance

Identifiers

PMID39231871

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.