Evidence map›Paper›PMID 39231966›Full record

ArticleNature communications2024

Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins.

Tom J Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K Bronowska, Pierre Genevaux, Tim R Blower

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tom J ArrowsmithDepartment of Biosciences, Durham University, Durham, UK.
Xibing XuLaboratoire de Microbiologie et Génétique Moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), Toulouse, France.ORCID 0000-0002-8055-8674
Shangze XuChemistry - School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, UK.ORCID 0000-0001-8736-2298
Ben UsherDepartment of Biosciences, Durham University, Durham, UK.
Peter StokesDepartment of Chemistry, Durham University, Durham, UK.
Megan GuestDepartment of Biosciences, Durham University, Durham, UK.ORCID 0009-0003-6128-2873
Agnieszka K BronowskaChemistry - School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, UK.
Pierre GenevauxLaboratoire de Microbiologie et Génétique Moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), Toulouse, France. pierre.genevaux@univ-tlse3.fr.ORCID 0000-0001-7539-3126
Tim R BlowerDepartment of Biosciences, Durham University, Durham, UK. timothy.blower@durham.ac.uk.ORCID 0000-0002-7390-6458

Funding

Academy of Medical Sciences SBF002\1104Fondation pour la Recherche Médicale (Foundation for Medical Research in France) EQU202403018015National Natural Science Foundation of China (National Science Foundation of China) 32000021RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/S022791/1
6 · The paper itself

Abstract

Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance. The Mycobacterium tuberculosis NTase toxin family, MenT, modifies tRNAs to block translation. MenT toxin activity can be stringently regulated by diverse MenA antitoxins. There has been no unifying mechanism linking antitoxicity across MenT homologues. Here we demonstrate through structural, biochemical, biophysical and computational studies that despite lacking kinase motifs, antitoxin MenA

Indexed as

Catalytic DomainMycobacterium tuberculosisNucleotidyltransferasesBacterial ProteinsBacterial ToxinsCrystallography, X-RayModels, MolecularPhosphorylationRNA, TransferBacterial ProteinsBacterial ToxinsNucleotidyltransferasesRNA, Transfer

Identifiers

PMID39231966
PMCPMC11375011

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.