Evidence map›Paper›PMID 39231981›Full record

ArticleNature communications2024

Hypothalamic-hindbrain circuit for consumption-induced fear regulation.

Qin Wang, Rui-Yue Sun, Jia-Xue Hu, Yan-Hui Sun, Chun-Yue Li, Huiqian Huang, Hao Wang, Xiao-Ming Li

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qin Wang *Department of Neurobiology and Department of Psychiatry of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0001-7081-6580
Rui-Yue Sun *Department of Neurobiology and Department of Psychiatry of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jia-Xue HuDepartment of Neurobiology and Department of Psychiatry of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yan-Hui SunDepartment of Neurobiology and Department of Psychiatry of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Chun-Yue LiDepartment of Neurobiology and Department of Psychiatry of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Huiqian HuangDepartment of Neurobiology and Department of Psychiatry of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hao WangDepartment of Neurobiology and Department of Psychiatry of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. wanghao890625@126.com.ORCID 0000-0002-3424-6522
Xiao-Ming LiDepartment of Neurobiology and Department of Psychiatry of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. lixm@zju.edu.cn.ORCID 0000-0002-8617-1702

Funding

China Postdoctoral Science Foundation 2019TQ0278National Natural Science Foundation of China (National Science Foundation of China) 31900723National Natural Science Foundation of China (National Science Foundation of China) 82001186National Natural Science Foundation of China (National Science Foundation of China) 82090030National Natural Science Foundation of China (National Science Foundation of China) 82090031
6 · The paper itself

Abstract

To ensure survival, animals must sometimes suppress fear responses triggered by potential threats during feeding. However, the mechanisms underlying this process remain poorly understood. In the current study, we demonstrated that when fear-conditioned stimuli (CS) were presented during food consumption, a neural projection from lateral hypothalamic (LH) GAD2 neurons to nucleus incertus (NI) relaxin-3 (RLN3)-expressing neurons was activated, leading to a reduction in CS-induced freezing behavior in male mice. LH

Indexed as

FearAnimalsConditioning, ClassicalEatingHypothalamic Area, LateralHypothalamusMaleMiceMice, Inbred C57BLNeural PathwaysNeuronsRelaxinRelaxin

Identifiers

PMID39231981
PMCPMC11375128

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.