ArticleNature2024
Immune system adaptation during gender-affirming testosterone treatment.
Erratum issued Registry-linked trialAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07394400 (A Comprehensive Assessment of the Impact of Gender-Affirming Hormone Therapy on Cardiovascular Risk, Metabolic Health, and Mood Disorders in Transgender Individuals.), which is not on this map. Cited by 92 papers.
0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comprehensive Assessment of the Impact of Gender-Affirming Hormone Therapy on Cardiovascular Risk, Metabolic Health, and Mood Disorders in Transgender Individuals.
Who cites it
92 citing papers in PubMed.
- HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial.Nature communications · 2025Trial
- Queer Science and Scientists Are Shaping the Future of Immunology.European journal of immunology · 2026Article
- Nationwide estimates of all-cause and cause-specific mortality among individuals with gender dysphoria in Sweden, 2001-2023: a register-based cohort study.EClinicalMedicine · 2026Article
- Sex differences in excess mortality during the COVID-19 pandemic: a longitudinal ecological analysis of 34 high-income countries.EClinicalMedicine · 2026Article
- Review
- A non-canonical androgen signaling pathway drives microglial activation and tau pathology in females.Research square · 2026Article
- Prenatal methylmercury exposure disrupts developmental trajectories and induces sex-specific toxicity in pubertal rats.Research square · 2026Article
- Special Issue: New Horizons in HIV and Reproductive Health Research: HIV Acquisition and Reproductive Health in Key Populations.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review).International journal of molecular medicine · 2026Review
- Impact of sex differences in adult and paediatric HIV-1 cure.Current opinion in HIV and AIDS · 2026Review
- Systemic testosterone induces structural, immunological, and sex steroid receptor changes in human XX skin.Scientific reports · 2026Article
- miR-29a-3p targets the PI3K/Akt signaling pathway to suppress inflammation and MMP-9-dependent matrix degradation in spinal tuberculosis.Journal of orthopaedic surgery and research · 2026Article
- Sex and gender differences in rheumatology: clinical impact and future directions.Nature reviews. Rheumatology · 2026Review
- Association between sex hormones and innate cytotoxic capacity of circulating and rectal mucosal immune cells.Clinical immunology communications · 2026Article
- T-cell distribution in the dorsal root ganglion across species, sex, and age.bioRxiv : the preprint server for biology · 2026Article
- Neurodevelopmental comorbidities in juvenile systemic autoimmune and autoinflammatory diseases.Nature reviews. Rheumatology · 2026Review
- Associations between plasma proteins and psychological wellbeing: evidence from over 20 years of the English Longitudinal Study of Ageing.Molecular psychiatry · 2026Article
- Immunoprofiling, sex- and age-related determinants of treatment response in paediatric, adolescent and young adult Hodgkin lymphoma.British journal of haematology · 2026Article
- Sex differences in immune responses to viruses, bacteria and vaccines.Nature immunology · 2026Review
- Sex matters: mechanistic insights into sex-driven patterns of autoimmunity and implications for pharmacotherapy.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
31 authors.
Tadepally Lakshmikanth *Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.ORCID 0000-0001-7256-5770
Camila Consiglio *Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.ORCID 0000-0002-8901-2328
Fabian SardhCenter for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden.
Rikard ForlinDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Jun WangDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Ziyang TanDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Hugo BarcenillaDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.ORCID 0000-0002-7255-362X
Lucie RodriguezDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.ORCID 0000-0002-3692-9060
Jamie SugrueTranslational Immunology Unit, Institut Pasteur, Paris, France.
Peri NooriCenter for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden.
Margarita IvanchenkoDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Laura Piñero PáezDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Laura GonzalezDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Constantin Habimana MugaboDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Anette JohnssonDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Henrik RybergDepartment of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
Åsa HallgrenCenter for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden.
Christian PouDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Yang ChenDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Jaromír MikešDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.ORCID 0000-0002-9941-7855
Anna JamesDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Per DahlqvistDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.ORCID 0000-0002-6471-9503
Jeanette WahlbergDepartment of Medicine, Örebro University, Örebro, Sweden.ORCID 0000-0003-4061-6830
Anders HagelinANOVA, Karolinska University Hospital, Stockholm, Sweden.
Mats HolmbergANOVA, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-2884-9981
Marie DegerbladANOVA, Karolinska University Hospital, Stockholm, Sweden.
Magnus IsakssonDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Darragh DuffyTranslational Immunology Unit, Institut Pasteur, Paris, France.ORCID 0000-0002-8875-2308
Olle KämpeCenter for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden.ORCID 0000-0001-6091-9914
Nils Landegren *Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden. nils.landegren@imbim.uu.se.
Petter Brodin *Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden. petter.brodin@ki.se.ORCID 0000-0002-8103-0046
Funding
Karolinska Institute
Abstract
Infectious, inflammatory and autoimmune conditions present differently in males and females. SARS-CoV-2 infection in naive males is associated with increased risk of death, whereas females are at increased risk of long COVID
Indexed as
TestosteroneTransgender PersonsAdultDatasets as TopicDendritic CellsFemaleHumansImmune SystemInterferon-gammaInterferon Type IInterleukin-15Interleukin-6Killer Cells, NaturalMaleMonocytesNF-kappa BIL15 protein, humanIL6 protein, humanInterferon-gammaInterferon Type IInterleukin-15Interleukin-6NF-kappa BTestosteroneTumor Necrosis Factor-alpha
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT07394400ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.