Evidence map›Paper›PMID 39232159›Full record

ArticleNature2024

Frontostriatal salience network expansion in individuals in depression.

Charles J Lynch, Immanuel G Elbau, Tommy Ng, Aliza Ayaz, Shasha Zhu, Danielle Wolk, Nicola Manfredi, Megan Johnson, Megan Chang, Jolin Chou and 24 more

Registry-linked trialAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07570108 (Precision Functional Mapping to Predict and Track ERP Response in Pediatric Obsessive-Compulsive Disorder), which is not on this map. Cited by 188 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07570108 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Precision Functional Mapping to Predict and Track ERP Response in Pediatric Obsessive-Compulsive Disorder: A Longitudinal fMRI Study

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2026 to 2031Enrolled0ConditionsObsessive-Compulsive DisorderArmsExposure and Response Prevention Therapy, Clinical Assessments, Research MRI Sessions
3 · Its place in the literature

Who cites it

188 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Heterogeneous brain alterations in treatment-resistant depression converge on common control networks.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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128 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Charles J LynchDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA. cjl2007@med.cornell.edu.ORCID 0000-0003-1936-9740
Immanuel G ElbauDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Tommy NgDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Aliza AyazDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Shasha ZhuDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Danielle WolkDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Nicola ManfrediDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Megan JohnsonDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-9330-4182
Megan ChangDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Jolin ChouDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Indira SummervilleDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Claire HoDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Maximilian LueckelLeibniz Institute for Resilience Research, Mainz, Germany.
Hussain BukhariDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Derrick BuchananDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4478-2844
Lindsay W VictoriaDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Nili SolomonovDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Eric GoldwaserDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Stefano MoiaNeuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.ORCID 0000-0002-2553-3327
Cesar Caballero-GaudesBasque Center on Cognition, Brain and Language, Donostia, Spain.
Jonathan DownarDepartment of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Fidel Vila-RodriguezDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-8273-8820
Zafiris J DaskalakisDepartment of Psychiatry, University of California, San Diego, CA, USA.
Daniel M BlumbergerDepartment of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-8422-5818
Kendrick KayCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
Amy AloysiIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Evan M GordonDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2276-5237
Mahendra T BhatiDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Nolan WilliamsDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Jonathan D PowerDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Benjamin ZebleyDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Logan GrosenickDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Faith M GunningDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-1854-9969
Conor ListonDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA. col2004@med.cornell.edu.ORCID 0000-0002-1639-5401

Funding

Efficacy of biomarker-guided rTMS for treatment resistant depressionR01MH118388 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI BHATI, MAHENDRA T, GUNNING, FAITH M · 2019 to 2025
$6.2M
Regulation of prefrontal cortical circuit function and reward-seeking behavior by stress-induced dendritic spine remodelingR01MH118451 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI Joshua Levitz, Conor M Liston · 2019 to 2026
$5.5M
RESEARCH TRAINING IN GERIATRIC MOOD DISORDERST32MH019132 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUNNING, FAITH M · 1990 to 2025
$3.4M
Scalable Biomarkers and Generative Digital Twins for Personalized Neurostimulation in DepressionR01MH131534 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LOGAN GROSENICK · 2022 to 2026
$3.2M
Positive valence systems engagement during social reward exposure psychotherapy for mid- and late-life depressionK23MH123864 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI SOLOMONOV, NILI · 2020 to 2024
$954k
Targeting salience network dysfunction in depression with individualized brain network mapping and TMSF32MH120989 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LYNCH, CHARLES JOSEPH · 2019 to 2021
$194k
NIMH NIH HHS F32 MH120989NIMH NIH HHS K23 MH123864NIMH NIH HHS R01 MH118388NIMH NIH HHS R01 MH118451NIMH NIH HHS R01 MH131534NIMH NIH HHS T32 MH019132Wellcome Trust
6 · The paper itself

Abstract

Decades of neuroimaging studies have shown modest differences in brain structure and connectivity in depression, hindering mechanistic insights or the identification of risk factors for disease onset

Indexed as

Brain MappingCorpus StriatumDepressionFrontal LobeNerve NetNeural PathwaysAdultAffectAnhedoniaFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedReproducibility of Results

Identifiers

PMID39232159
PMCPMC11410656

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.