Evidence map›Paper›PMID 39232165›Full record

ArticleNature2024

Alternating high-fat diet enhances atherosclerosis by neutrophil reprogramming.

Jean-Rémi Lavillegrand, Rida Al-Rifai, Sara Thietart, Théo Guyon, Marie Vandestienne, Raphael Cohen, Vincent Duval, Xiaodan Zhong, Daniel Yen, Mumin Ozturk and 21 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. TheJournal of the American Heart Association · 2026
    Article
  13. CIITA/PRMT5 promote CD4BMC medicine · 2026
    Article
  14. Article
  15. Review
  16. MTHFD2: a promising metabolic checkpoint for diseases.Journal of translational medicine · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Jean-Rémi LavillegrandParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.
Rida Al-RifaiParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.ORCID 0000-0002-6976-0011
Sara ThietartParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.
Théo GuyonParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.
Marie VandestienneParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.ORCID 0000-0002-6947-9852
Raphael CohenParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.
Vincent DuvalParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.
Xiaodan ZhongParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.ORCID 0000-0001-5268-3905
Daniel YenDepartment of Cell and Developmental Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4101-9448
Mumin OzturkDepartment of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University FNWI, Nijmegen, The Netherlands.
Yutaka NegishiDepartment of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University FNWI, Nijmegen, The Netherlands.
Joanne KonkelLydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.ORCID 0000-0002-6525-5499
Emmanuel PinteauxDivision of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Olivia LenoirParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.ORCID 0000-0001-8107-6987
Jose VilarParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.ORCID 0000-0002-9136-7726
Ludivine LauransParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.
Bruno EspositoParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.
Marius BredonGastroenterology Department, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Paris, France.
Harry SokolGastroenterology Department, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Paris, France.ORCID 0000-0002-2914-1822
Marc DiedisheimClinique Saint Gatien Alliance (NCT+), Saint-Cyr-sur-Loire, France.ORCID 0000-0002-0418-1107
Antoine-Emmanuel SalibaHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany.ORCID 0000-0001-8539-2784
Alma ZerneckeInstitute of Experimental Biomedicine, University Hospital Wuerzburg, Würzburg, Germany.ORCID 0000-0001-8551-4729
Clément CochainInstitute of Experimental Biomedicine, University Hospital Wuerzburg, Würzburg, Germany.ORCID 0000-0002-0340-1745
Jessica HaubQuantitative Systems Biology, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Alain TedguiParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.ORCID 0000-0002-7229-4875
Nancy A SpeckDepartment of Cell and Developmental Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1893-582X
Soraya TalebParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France.ORCID 0000-0002-6650-619X
Musa M MhlangaDepartment of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University FNWI, Nijmegen, The Netherlands.ORCID 0000-0003-1381-3409
Andreas SchlitzerQuantitative Systems Biology, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0000-0001-7662-3712
Niels P RiksenDepartment of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID 0000-0001-9197-8124
Hafid Ait-OufellaParis Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France. hafid.aitoufella@inserm.fr.ORCID 0000-0002-2955-0183

Funding

Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zahi A. Fayad · 2017 to 2026
$24.3M
HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1M
Expansion of cardiac and hematopoietic progenitors by Wnt and NotchU01HL100405 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, JONATHAN A., MORRISEY, EDWARD E · 2009 to 2015
$8.1M
The role of inflammation in driving leukemogenesis in germline predisposition syndromesU01CA257666 · NCI · UNIVERSITY OF CHICAGO · PI AGARWAL, ANUPRIYA, BRESNICK, EMERY H. · 2022 to 2025
$2.5M
NCI NIH HHS U01 CA257666NHLBI NIH HHS P01 HL131478NHLBI NIH HHS T32 HL007439NHLBI NIH HHS U01 HL100405
6 · The paper itself

Abstract

Systemic immune responses caused by chronic hypercholesterolaemia contribute to atherosclerosis initiation, progression and complications

Indexed as

AtherosclerosisCellular ReprogrammingDiet, High-FatNeutrophilsAnimalsApolipoproteins EBone Marrow CellsCore Binding Factor Alpha 2 SubunitDNA-Binding ProteinsExtracellular TrapsFemaleInflammationInterleukin-1betaMaleMiceMice, Inbred C57BLApoe protein, mouseApolipoproteins ECore Binding Factor Alpha 2 SubunitDNA-Binding ProteinsIL1B protein, mouseInterleukin-1betaLdlr protein, mouseRag2 protein, mouseReceptors, LDLRunx1 protein, mouse

Identifiers

PMID39232165
PMCPMC12019644

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.