Evidence map›Paper›PMID 39232748›Full record

ArticleBMC endocrine disorders2024

Effects of a Paleolithic diet compared to a diabetes diet on leptin binding inhibition in secondary analysis of a randomised cross-over study.

Maelán Fontes-Villalba, Yvonne Granfeldt, Kristina Sundquist, Ashfaque A Memon, Anna Hedelius, Pedro Carrera-Bastos, Tommy Jönsson

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00435240 (Paleolithic Diet in the Treatment of Diabetes Type 2 in Primary Health Care), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00435240 phase2completednot on this map

Paleolithic Diet in the Treatment of Diabetes Type 2 in Primary Health Care

TypeinterventionalSponsorLund University HospitalRan2005 to 2007Enrolled13ConditionsDiabetes Mellitus, Type 2ArmsPaleolithic diet
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maelán Fontes-VillalbaCenter for Primary Health Care Research. Department of Clinical Sciences. Malmö, Lund University, Malmö, Sweden. maelan.fontes_villalba@med.lu.se.
Yvonne GranfeldtDeparment of Process and Life Science Engineering, Lund University, Lund, Sweden.
Kristina SundquistCenter for Primary Health Care Research. Department of Clinical Sciences. Malmö, Lund University, Malmö, Sweden.
Ashfaque A MemonCenter for Primary Health Care Research. Department of Clinical Sciences. Malmö, Lund University, Malmö, Sweden.
Anna HedeliusCenter for Primary Health Care Research. Department of Clinical Sciences. Malmö, Lund University, Malmö, Sweden.
Pedro Carrera-BastosCenter for Primary Health Care Research. Department of Clinical Sciences. Malmö, Lund University, Malmö, Sweden.
Tommy JönssonCenter for Primary Health Care Research. Department of Clinical Sciences. Malmö, Lund University, Malmö, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBeneficial effects from practising a Paleolithic diet as compared to a diabetes diet on weight, waist circumference, satiety, leptin, HbA1c and glucose control in randomised controlled trial participants with type 2 diabetes could be due to lower leptin resistance. Support for this hypothesis comes from an in vitro experiment that showed that digested wheat gluten, which is excluded from a Paleolithic diet, inhibits leptin from binding to its receptor, thus indicating a possible dietary cause of leptin resistance. However, the clinical relevance of the latter finding is unclear since removal of enzyme activity from the gluten digest by heat treatment also abolished leptin binding inhibition. Assessment of leptin binding inhibition in vivo is possible by comparison of total leptin levels with those of 'biologically active' leptin bound to its receptor (bioLep).

objectivesTo assess the effects of a Paleolithic diet compared to a diabetes diet on leptin binding inhibition and to replicate our in vitro study.

methodsBioLep and total leptin levels were measured in secondary analysis of fasting plasma samples from our open label random order three plus three-month long cross-over trial performed in 2005-2007, that compared a Paleolithic diet with a diabetes diet in participants with type 2 diabetes without insulin treatment (per protocol). BioLep was also measured in vitro for known recombinant leptin concentrations incubated with a series of concentrations of 10 kDa spin-filtered digested wheat gluten, with or without prior heat treatment, at 100ºC for 30 min and centrifugation.

resultsThere was no difference between diets when comparing differences between bioLep and total leptin levels and their ratio in the 13 participants, three women and 10 men, aged 52-74 years with a mean BMI of 30 kg/m

conclusionsWe found no leptin binding inhibition after the Paleolithic or diabetes diet, possibly due to its abolishment from cooking-related heat treatment of wheat gluten.

trial registrationRegistered on 14/02/2007 at ClinicalTrials.gov Identifier: NCT00435240.

Indexed as

Cross-Over StudiesDiabetes Mellitus, Type 2Diet, DiabeticDiet, PaleolithicLeptinAgedClinical Trials, Phase II as TopicFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicLeptinBioLepLeptinLeptin resistancePaleolithic dietType 2 diabetesWheat gluten

Identifiers

PMID39232748
PMCPMC11373484

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.