Evidence map›Paper›PMID 39232779›Full record

Trial reportBMC medicine2024

Effect of salt substitution on fracture-a secondary analysis of the Salt Substitute and Stroke Study (SSaSS).

Faxuan Wang, Yangyang Pi, Yi Zhao, Yuhong Zhang, Bo Zhou, Zhifang Li, Jixin Sun, Yan Yu, Maoyi Tian, Minghui Yang and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02092090 (A LARGE-SCALE CLUSTER RANDOMIZED TRIAL TO DETERMINE THE EFFECTS OF SODIUM REDUCTION ON STROKE), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02092090 nacompletednot on this map

A LARGE-SCALE CLUSTER RANDOMIZED TRIAL TO DETERMINE THE EFFECTS OF SODIUM REDUCTION ON STROKE: THE CHINA SALT SUBSTITUTE AND STROKE STUDY (SSaSS)

TypeinterventionalSponsorThe George InstituteRan2014 to 2020Enrolled20,996ConditionsStrokeArmsDietary sodium reduction
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Faxuan WangSchool of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
Yangyang PiSchool of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
Yi ZhaoSchool of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China. zhaoyi751114@hotmail.com.ORCID 0000-0002-0958-0350
Yuhong ZhangSchool of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
Bo ZhouDepartment of Evidencebased Medicine, First Hospital of China Medical University, Shenyang, China.
Zhifang LiSchool of Public Health, Changzhi Medical College, Changzhi, China.
Jixin SunDepartment of Noncommunicable Disease Prevention and Control, Center for Disease Control of Hebei Province, Shijiazhuang, China.
Yan YuSchool of Public Health, Xi'an Jiaotong University School of Medicine, Xi'an, China.
Maoyi TianSchool of Public Health, Harbin Medical University, Harbin, China.
Minghui YangDepartment of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.
Liping HuangThe George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
Hongyi SongThe George Institute for Global Health China, Beijing, China.
Bruce NealThe George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
Katrina R KissockThe George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssociations of dietary sodium and potassium intake with fracture risk are inconsistent and the effects of salt substitute on fracture incidence are unknown. We assessed the effect of salt substitute compared to regular salt intake on fracture incidence using data from the Salt Substitute and Stroke Study (SSaSS).

methodsSSaSS was a cluster-randomized controlled trial conducted in 600 villages in northern China. Villages were randomly allocated into intervention and control groups in a 1:1 ratio. Salt substitute was provided to intervention villages and control villages continued regular salt use for 5 years. The primary outcome for this secondary analysis was the incidence of all fractures. Secondary outcomes included incidence of vertebral fracture, non-vertebral fracture, and fracture of unknown or non-specific location.

results20,995 participants were included in this study, and 821 fractures occurred during follow-up. Intention-to-treat analyses showed no differences between the salt substitute and regular salt groups in the incidence of all fractures (rate ratio (RR) 0.96; 95% CI 0.81 to 1.14), vertebral fracture (RR 0.82; 95% CI 0.53 to 1.26), non-vertebral fracture (RR 1.05; 95% CI 0.86 to 1.29), or fracture of unknown or non-specific location (RR 0.80; 95% CI 0.54 to 1.18).

conclusionsUse of salt substitute compared to regular salt had no detectable effect on the incidence of fracture in a population at high risk of cardiovascular disease and fracture.

trial registrationClinicalTrials.gov, NCT02092090. Registered on March 12, 2014.

Indexed as

Fractures, BoneSodium Chloride, DietaryAgedChinaFemaleHumansIncidenceMaleMiddle AgedStrokeSodium Chloride, DietaryFractureLow-sodium saltOsteoporosisRandomized-controlled trialSalt substitute

Identifiers

PMID39232779
PMCPMC11376003

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.