Evidence map›Paper›PMID 39232846›Full record

ArticleJournal of cellular and molecular medicine2024

Histone deacetylase 6 controls cardiac fibrosis and remodelling through the modulation of TGF-β1/Smad2/3 signalling in post-infarction mice.

Junqiao Fang, Shangzhi Shu, Hui Dong, Xueling Yue, Jinshun Piao, Shuyan Li, Lan Hong, Xian Wu Cheng

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Increased Dipeptidyl Peptidase-4 Promotes Adipose Inflammation and Dysfunction in Mice Under Chronic Stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Dexmedetomidine Reduces Chronic Stress-Related Thrombosis in a Mouse FeClFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  10. Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF-β/Smad2/3 Signaling in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  11. Dipeptidyl peptidase-4 deficiency prevents chronic stress-induced cardiac remodeling and dysfunction in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junqiao FangDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, China.
Shangzhi ShuDepartment of Cardiology, The First Hospital of Jilin University, Changchun, Jilin, China.
Hui DongDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanjin, Jilin, China.
Xueling YueDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, China.
Jinshun PiaoDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, China.
Shuyan LiDepartment of Cardiology, The First Hospital of Jilin University, Changchun, Jilin, China.
Lan HongDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanjin, Jilin, China.
Xian Wu ChengDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, China.ORCID 0000-0002-9758-0632

Funding

National Natural Science Foundation of China 81770485National Natural Science Foundation of China 82070299National Natural Science Foundation of China 82350065National Natural Science Foundation of China 82370424
6 · The paper itself

Abstract

Histone deacetylase 6 (HDAC6) belongs to the class IIb group of the histone deacetylase family, which participates in remodelling of various tissues. Herein, we sought to examine the potential regulation of HDAC6 in cardiac remodelling post-infarction. Experimental myocardial infarction (MI) was created in HDAC6-deficient (HDAC6

Indexed as

FibrosisHistone Deacetylase 6Myocardial InfarctionSignal TransductionSmad2 ProteinSmad3 ProteinTransforming Growth Factor beta1Ventricular RemodelingAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutMyocardiumHdac6 protein, mouseHistone Deacetylase 6Smad2 ProteinSmad2 protein, mouseSmad3 ProteinTransforming Growth Factor beta1cardiac fibroblastcardiac fibrosiscollagenhistone deacetylases 6myocardial infarction

Identifiers

PMID39232846
PMCPMC11374528

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.