Evidence map›Paper›PMID 39233208›Full record

ArticleThe journal of pain2024

Uncoupling the CRMP2-Ca

Heather N Allen, Sara Hestehave, Paz Duran, Tyler S Nelson, Rajesh Khanna

Abstract read
In one paragraph

Article in The journal of pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Dual-Targeted Inhibition of PARNanomaterials (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Ion channels as therapeutic targets in osteoarthritis.Trends in pharmacological sciences · 2025
    Review
  10. Article
  11. R and S enantiomers of CBD3063, a CaNeurobiology of pain (Cambridge, Mass.)
    Article
  12. Engineering Nanoscale Drug Delivery Systems for Pain.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Heather N AllenDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, Florida.
Sara HestehaveDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, New York; Department of Experimental Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Paz DuranDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, New York.
Tyler S NelsonDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, Florida.
Rajesh KhannaDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, Florida. Electronic address: r.khanna@ufl.edu.

Funding

Sentrin proteases, CRMP2 deSUMOylation, and Chronic PainR01NS120663 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2020 to 2021
$2.6M
Validation of Neuropilin-1 Receptor Signaling in Nociceptive ProcessingRF1NS131165 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2023 to 2023
$2.0M
Antagonists of CRMP2 Phosphorylation for Chemotherapy-Induced Peripheral NeuropathyR61NS126026 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2022 to 2022
$1.4M
Dissecting the Parabrachial Nucleus’s Role in the Development and Maintenance of Neuropathic PainK00NS124190 · NINDS · UNIVERSITY OF FLORIDA · PI Tyler Scott Nelson · 2023 to 2026
$346k
Neuropeptide Y1 Receptor-Expressing Neurons in the Lateral Parabrachial Nucleus in Neuropathic PainF32NS128392 · NINDS · UNIVERSITY OF FLORIDA · PI ALLEN, HEATHER NOEL · 2023 to 2025
$217k
NINDS NIH HHS F32 NS128392NINDS NIH HHS K00 NS124190NINDS NIH HHS R01 NS120663NINDS NIH HHS R61 NS126026NINDS NIH HHS RF1 NS131165
6 · The paper itself

Abstract

Osteoarthritis (OA) represents a significant pain challenge globally, as current treatments are limited and come with substantial and adverse side effects. Voltage-gated calcium channels have proved to be pharmacologically effective targets, with multiple Food and Drug Administration-approved Ca

Indexed as

Calcium Channels, N-TypeDisease Models, AnimalIntercellular Signaling Peptides and ProteinsNerve Tissue ProteinsAnalgesicsAnimalsArthralgiaMaleRatsRats, Sprague-DawleyAnalgesicsCacna1b protein, ratCalcium Channels, N-Typecollapsin response mediator protein-2Intercellular Signaling Peptides and ProteinsNerve Tissue ProteinsCa(V)2.2collapsin response mediator protein 2Osteoarthritis painvoltage-gated calcium channel 2.2

Identifiers

PMID39233208
PMCPMC11560641

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.