Evidence map›Paper›PMID 39233681›Full record

ArticleFrontiers in neurology2024

Association of higher triglyceride-glucose index and triglyceride-to-high-density lipoprotein cholesterol ratio with early neurological deterioration after thrombolysis in acute ischemic stroke patients.

Mingzhu Deng, Kangping Song, Wei Xu, Guohua He, Jue Hu, Hui Xiao, Nina Zhou, Sufen Chen, Guilan Xu, Yangping Tong and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mingzhu Deng *Department of Neurology, Brain Hospital of Hunan Province, The Second People's Hospital of Hunan Province, Changsha, China.
Kangping Song *Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Wei Xu *Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Guohua HeDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Jue HuDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Hui XiaoDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Nina ZhouDepartment of Neurology, Brain Hospital of Hunan Province, The Second People's Hospital of Hunan Province, Changsha, China.
Sufen ChenDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Guilan XuDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Yangping TongDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Dan ZhangDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Zhen WangDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Fangyi LiDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Insulin resistance (IR) can predict the prognosis of patients suffering from cerebrovascular disorders. The triglyceride-glucose (TyG) index and triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio have been confirmed to be easy and reliable indicators of IR. However, the relationships between the TyG index or TG/HDL-C ratio and early neurological deterioration (END) after thrombolysis in patients with acute ischemic stroke (AIS) are uncertain. Methods: A retrospective analysis of 1,187 patients diagnosed with AIS who underwent intravenous thrombolysis between January 2018 and February 2024 was performed. Post-thrombolysis END was defined as an increase in the National Institutes of Health Stroke Scale (NIHSS) score of ≥4 within 24 h after thrombolysis. Logistic regression analysis was performed to explore the relationships of the TyG index and TG/HDL-C ratio with post-thrombolysis END. Receiver operating characteristic (ROC) analysis was used to assess the ability of the TyG index and TG/HDL-C ratio to discriminate post-thrombolysis END. Results: Among the 1,187 recruited patients, 179 (15.08%) were diagnosed with post-thrombolysis END, and 1,008 (84.92%) were diagnosed with non-END. A binary logistic regression model indicated that the TyG index (odds ratio [OR], 2.015; 95% confidence interval [CI] 1.964-2.414, Conclusion: This study indicates that the TyG index and TG/HDL-C ratio can be used as prognostic factors to predict post-thrombolysis END.

Indexed as

acute ischemic strokeearly neurological deteriorationintravenous thrombolysistriglyceride–glucose indextriglyceride-to-high-density lipoprotein cholesterol ratio

Identifiers

PMID39233681
PMCPMC11371550

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.