Evidence map›Paper›PMID 39234983›Full record

ArticleBiomarkers in medicine2024

Perspective: metabolomics has the potential to change the landscape of kidney transplantation diagnostics.

Dirk R J Kuypers, Jurre J Kamphorst, Henriette de Loor, Elizabeth M O'Day

Abstract read
In one paragraph

Article in Biomarkers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dirk R J KuypersDepartment of Nephrology & Renal Transplantation, University Hospitals Leuven, Belgium.ORCID 0000-0001-5546-9680
Jurre J KamphorstOlaris, Inc., Framingham, MA 01702, USA.ORCID 0000-0002-2042-5474
Henriette de LoorDepartment of Nephrology & Renal Transplantation, University Hospitals Leuven, Belgium.ORCID 0000-0003-4421-6340
Elizabeth M O'DayOlaris, Inc., Framingham, MA 01702, USA.ORCID 0000-0001-5854-9029

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplantation is the most efficient renal replacement therapy. Current diagnostics for monitoring graft health are either invasive or lack precision. Metabolomics is an emerging discipline focused on the analysis of the small molecules involved in metabolism. Given the kidneys' central role in metabolic homeostasis and previous observations of altered metabolites correlating with restricted kidney graft function, metabolomics is highly promising for the discovery of novel biomarkers and the development of novel diagnostics. In this perspective, we summarize the known metabolic roles for the kidney, discuss biomarkers of graft health and immune status emerging from metabolomics research, and provide our perspective on how these and future findings can be integrated in clinical practice to enable precision diagnostics.

Indexed as

BiomarkersKidney TransplantationMetabolomicsHumansKidneyBiomarkersallograft statusdiagnosticsgraft injurykidney transplantmetabolitesmetabolomicsrejection

Identifiers

PMID39234983
PMCPMC11457662

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.