Evidence map›Paper›PMID 39235608›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2024

Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates.

Balamurugan Ramatchandirin, Marie Amalie Balamurugan, Suneetha Desiraju, Yerin Chung, Boguslaw S Wojczyk, Krishnan MohanKumar

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Balamurugan RamatchandirinDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Marie Amalie BalamuruganDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Suneetha DesirajuDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Yerin ChungDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Boguslaw S WojczykDepartment of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Krishnan MohanKumarDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA. mokrishnan@unmc.edu.

Funding

Liver-Gut Axis in Neonatal Anemia and Its Role in RBC Transfusion Associated Gut InjuryR01HL163043 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Mohan Kumar Krishnan · 2023 to 2026
$1.9M
Effect of Platelet Transfusions on Neonatal Intestinal InjuryR01HL133022 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2017 to 2020
$1.6M
RBC TRANSFUSION IN ANEMIC NEONATES LEADS TO SYSTEMIC INFLAMMATORY RESPONSE SYNDROMER21HD105880 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KRISHNAN, MOHAN KUMAR · 2021 to 2022
$433k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R21HD105880NHLBI NIH HHS R01 HL133022NHLBI NIH HHS R01 HL163043NHLBI NIH HHS R01HL163043NICHD NIH HHS R21 HD105880
6 · The paper itself

Abstract

objectiveRBC transfusions (RBCT) are life-saving treatment for premature and critically ill infants. However, the procedure has been associated with the development of systemic inflammatory response syndrome (SIRS) and potentially multiple organ dysfunction syndrome (MODS) in neonates. The present study aimed to investigate the mechanisms of RBCT-related SIRS in severely anemic murine neonates.

methodsC57BL/6 (WT), TLR4

resultsAnemic murine pups developed cytokine storm within 2 h of receiving stored RBCs, which increased until 6 h post-transfusion, as compared to non-anemic mice receiving stored RBCTs ("transfusion controls"), in a TLR4-independent fashion. Nonetheless, severely anemic pups had elevated circulating endotoxin levels, thereby sensitizing circulating monocytes to presynthesize proinflammatory cytokines (IFN-γ, IL-1β, TNF-α, IL-6, MIP-1α, MIP-1β, MIP2, LIX) and express trem1. Silencing trem1 expression in Raw264.7 cells mitigated both endotoxin-associated presynthesis of proinflammatory cytokines and the RBCT-induced release of inflammatory cytokines. Indeed, myeloid-specific trem1

conclusionSevere anemia-associated low-grade inflammation sensitizes monocytes to enhance the synthesis of proinflammatory cytokines and trem1. In this setting, RBCTs further activate these monocytes, thereby inducing SIRS. Inhibiting trem1 in myeloid cells, including monocytes, alleviates the inflammatory response associated with the combined effects of anemia and RBCTs in murine neonates.

Indexed as

AnemiaCytokinesErythrocyte TransfusionMice, Inbred C57BLMice, KnockoutSystemic Inflammatory Response SyndromeToll-Like Receptor 4Triggering Receptor Expressed on Myeloid Cells-1AnimalsAnimals, NewbornLipopolysaccharidesMiceCytokinesLipopolysaccharidesTlr4 protein, mouseToll-Like Receptor 4TREM1 protein, mouseTriggering Receptor Expressed on Myeloid Cells-1MonocytesNeonatal anemiaProinflammatory cytokinesSystemic inflammatory response syndromeTriggered myeloid receptor protein 1

Identifiers

PMID39235608
PMCPMC11540732

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.