Evidence map›Paper›PMID 39235945›Full record

ArticleCell reports2024

Acute and persistent responses after H5N1 vaccination in humans.

Richard Apps, Angélique Biancotto, Julián Candia, Yuri Kotliarov, Shira Perl, Foo Cheung, Rohit Farmer, Matthew P Mulè, Nicholas Rachmaninoff, Jinguo Chen and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Constraints and tunability of antigen-agnostic memory durability.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Richard AppsNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Angélique BiancottoNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Julián CandiaNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Yuri KotliarovNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA; Biometric Research Program, Division of Cancer Treatment and Diagnosis, NCI, NIH, Rockville, MD, USA.
Shira PerlNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Foo CheungNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Rohit FarmerNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Matthew P MulèMultiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; NIH Oxford-Cambridge Scholars Program, Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, UCB2 0QQ Cambridge, UK.
Nicholas RachmaninoffMultiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Jinguo ChenNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Andrew J MartinsMultiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Rongye ShiNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Huizhi ZhouNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Neha BansalMultiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Paula SchumNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Matthew J OlnesNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Pedro Milanez-AlmeidaNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Kyu Lee HanNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Brian SellersNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Mario CorteseInstitute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Thomas HaganInstitute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Nadine RouphaelHope Clinic of the Emory Vaccine Center, Decatur, GA 30030, USA.
Bali PulendranInstitute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA; Hope Clinic of the Emory Vaccine Center, Decatur, GA 30030, USA.
Lisa KingDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993 USA.
Jody ManischewitzDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993 USA.
Surender KhuranaDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993 USA.
Hana GoldingDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993 USA.
Robbert G van der MostGSK, Rixensart, Belgium.
Howard B DicklerNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.
Ronald N GermainNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Pamela L SchwartzbergNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA; Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
John S TsangNIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA; Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; Center for Systems and Engineering Immunology, Departments of Immunobiology and Biomedical Engineering, Yale University, New Haven, CT 06520, USA. Electronic address: john.tsang@yale.edu.

Funding

VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Integrative analysis and modeling of human immune responses and pathologiesZIAAI001152 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TSANG, JOHN · 2011 to 2022
$14.1M
Systems biological assessment of T cell responses to vaccinationU19AI167903 · NIAID · STANFORD UNIVERSITY · PI BALI PULENDRAN · 2022 to 2026
$13.2M
Drivers of individual variation in influenza vaccine response and protection from infectionR01AI170116 · NIAID · UNIVERSITY OF CHICAGO · PI Sarah Cobey, John S Tsang · 2022 to 2026
$7.2M
Intramural NIH HHS ZIA AI001152NIAID NIH HHS R01 AI170116NIAID NIH HHS U19 AI057266
6 · The paper itself

Abstract

To gain insight into how an adjuvant impacts vaccination responses, we use systems immunology to study human H5N1 influenza vaccination with or without the adjuvant AS03, longitudinally assessing 14 time points including multiple time points within the first day after prime and boost. We develop an unsupervised computational framework to discover high-dimensional response patterns, which uncover adjuvant- and immunogenicity-associated early response dynamics, including some that differ post prime versus boost. With or without adjuvant, some vaccine-induced transcriptional patterns persist to at least 100 days after initial vaccination. Single-cell profiling of surface proteins, transcriptomes, and chromatin accessibility implicates transcription factors in the erythroblast-transformation-specific (ETS) family as shaping these long-lasting signatures, primarily in classical monocytes but also in CD8

Indexed as

Influenza A Virus, H5N1 SubtypeInfluenza, HumanInfluenza VaccinesVaccinationAdjuvants, ImmunologicAdultCD8-Positive T-LymphocytesFemaleHumansMaleTranscriptomeAdjuvants, ImmunologicInfluenza Vaccinesadjuvantantigen-agnostic memorybaseline immune stateCP: ImmunologyCP: Microbiologyimmune response dynamicssingle cell analysissystems immunologytrained immunityvaccine

Identifiers

PMID39235945
PMCPMC11949244

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.