Evidence map›Paper›PMID 39236875›Full record

ArticleThe Journal of biological chemistry2024

Perturbations in mitochondrial metabolism associated with defective cardiolipin biosynthesis: An in-organello real-time NMR study.

Antonio J Rua, Wayne Mitchell, Steven M Claypool, Nathan N Alder, Andrei T Alexandrescu

Abstract read
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In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. What can ATP content tell us about Barth syndrome muscle phenotypes?Journal of translational genetics and genomics · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Antonio J RuaDepartment of Molecular and Cellular Biology, University of Connecticut, Storrs, Connecticut, USA.
Wayne MitchellDepartment of Molecular and Cellular Biology, University of Connecticut, Storrs, Connecticut, USA.
Steven M ClaypoolDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Mitochondrial Phospholipid Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nathan N AlderDepartment of Molecular and Cellular Biology, University of Connecticut, Storrs, Connecticut, USA. Electronic address: nathan.alder@uconn.edu.
Andrei T AlexandrescuDepartment of Molecular and Cellular Biology, University of Connecticut, Storrs, Connecticut, USA. Electronic address: andrei.alexandrescu@uconn.edu.

Funding

First-in-class peptide therapeutics for mitochondrial disorders: molecular mechanism of action and optimization of designR01AG065879 · NIA · UNIVERSITY OF CONNECTICUT STORRS · PI ALDER, NATHAN N · 2020 to 2024
$2.6M
NIA NIH HHS R01 AG065879
6 · The paper itself

Abstract

Mitochondria are central to cellular metabolism; hence, their dysfunction contributes to a wide array of human diseases. Cardiolipin, the signature phospholipid of the mitochondrion, affects proper cristae morphology, bioenergetic functions, and metabolic reactions carried out in mitochondrial membranes. To match tissue-specific metabolic demands, cardiolipin typically undergoes an acyl tail remodeling process with the final step carried out by the phospholipid-lysophospholipid transacylase tafazzin. Mutations in tafazzin are the primary cause of Barth syndrome. Here, we investigated how defects in cardiolipin biosynthesis and remodeling impacts metabolic flux through the TCA cycle and associated yeast pathways. Nuclear magnetic resonance was used to monitor in real-time the metabolic fate of

Indexed as

CardiolipinsMitochondriaSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAcyltransferasesBarth SyndromeCitric Acid CycleHumansMagnetic Resonance SpectroscopyPyruvic AcidAcyltransferasesCardiolipinsPyruvic AcidSaccharomyces cerevisiae ProteinsTaz1 protein, S cerevisiae3-methylglutaconic acid (3MGA)adenosine triphosphate (ATP)Barth syndrome (BTHS)Krebs cyclemetabolic diseasemitochondrial respirationnuclear magnetic resonance (NMR)tricarboxylic acid (TCA) cycle

Identifiers

PMID39236875
PMCPMC11470594

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.