Trial reportNature communications2024
Effect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controlled Trial.
Trial report in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of autologous platelet-rich plasma in recurrent implantation failure: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Extended embryo culture and cumulative live birth in patients with limited embryos.Journal of assisted reproduction and genetics · 2026Article
- Redefining success in assisted reproductive technologies: the Embryo-Maternal-Offspring Continuum Framework.Journal of assisted reproduction and genetics · 2026Review
- Cleavage stage versus blastocyst stage transfers in patients with a single zygote: an emulated target trial.Human reproduction (Oxford, England) · 2026Article
- Article
- Association between endometrial thickness and cumulative live birth rate in one oocyte-retrieval cycle: a retrospective cohort study including 26,127 patients.BMC pregnancy and childbirth · 2026Article
- Machine learning-based endometrial ultrasound radiomics habitat analysis for predicting pregnancy outcomes after embryo transfer.Journal of ovarian research · 2026Article
- Impact of intrauterine infusion of human umbilical cord blood mononuclear cells on reproductive outcomes in patients with thin endometrium undergoing frozen embryo transfer.Frontiers in cell and developmental biology · 2026Article
- An early prediction model for high-quality blastocyst development based on ANA titer and baseline demographic characteristics in the first IVF/ICSI cycle.Journal of ovarian research · 2025Article
- Single frozen-thawed blastocyst derived from poor-grade Day 3 embryo is not associated with adverse neonatal outcomes: a retrospective cohort study.Archives of gynecology and obstetrics · 2025Article
- Factors influencing the birth weight of ART-conceived offspring.Journal of assisted reproduction and genetics · 2025Review
- Nursing support for testicular sperm aspiration and intracytoplasmic sperm injection in patients with high paraplegia: a retrospective case series.Basic and clinical andrology · 2025Article
- A thinner endometrium is associated with a greater risk of preterm delivery after fresh cleavage embryo transfer but not after blastocyst transfer: a retrospective cohort study of 11,111 singleton live births.Frontiers in endocrinology · 2025Article
- The impact of hCG trigger versus dual trigger on reproductive outcomes in elderly infertile women: a retrospective cohort study.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this multicenter, non-inferiority, randomized trial, we randomly assigned 992 women undergoing in-vitro fertilization (IVF) with a good prognosis (aged 20-40, ≥3 transferrable cleavage-stage embryos) to strategies of blastocyst-stage (n = 497) or cleavage-stage (n = 495) single embryo transfer. Primary outcome was cumulative live-birth rate after up to three transfers. Secondary outcomes were cumulative live-births after all embryo transfers within 1 year of randomization, pregnancy outcomes, obstetric-perinatal complications, and livebirths outcomes. Live-birth rates were 74.8% in blastocyst-stage group versus 66.3% in cleavage-stage group (relative risk 1.13, 95%CI:1.04-1.22; P
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.