Backtracking childhood leukaemia to birth: A battle of addition.

Abstract read

In one paragraph

Article in British journal of haematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Logan G SpectorDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-2516-0222

Adam J de SmithCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-4880-7543

Funding

Backtracking Leukemia-Typical Somatic Alterations in Cord Blood at Single-cell ResolutionR01CA262012 · NCI · UNIVERSITY OF MINNESOTA · PI DE SMITH, ADAM, SPECTOR, LOGAN G. · 2021 to 2025

$2.9M

NCI NIH HHS R01 CA262012

6 · The paper itself

Abstract

Paediatric leukaemia has a long tail of driver mutations each of which must be 'backtracked' to samples taken at birth to identify the prenatal origin of a subtype. Presently, Bardini et al. describe the first successful backtracking of an NUTM1 rearrangement, which sheds light on the biology of this particular alteration. Continued backtracking of NUTM1 rearrangements, and all leukaemia-typical somatic alterations, is necessary to fully understand the prenatal origin of these diseases. Commentary on: Bardini et al. Prenatal origin of NUTM1 gene rearrangement in infant B-cell precursor acute lymphoblastic leukaemia. Br J Haematol 2024; 205:1883-1888.

Indexed as

Gene RearrangementChildFemaleHumansInfantInfant, NewbornPrecursor B-Cell Lymphoblastic Leukemia-Lymphomaacute lymphoblastic leukemiainfant B‐cell precursorleukemia‐forming NUTM1 rearrangement

Identifiers

PMID39238151

DOI10.1111/bjh.19747

PMCPMC12150861

What Socratic holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.