Evidence map›Paper›PMID 39238188›Full record

ArticleInternational journal of stem cells2024

Generation of an Isogenic Hereditary Hemorrhagic Telangiectasia Model via Prime Editing in Human Induced Pluripotent Stem Cells.

Min Woo Kim, Kyu Sik Jeong, Jin Kim, Seul-Gi Lee, C-Yoon Kim, Hyung Min Chung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min Woo KimCollege of Veterinary Medicine, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0000-0002-6597-4522
Kyu Sik JeongCollege of Veterinary Medicine, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0009-0003-4231-3750
Jin KimDepartment of Physiology, College of Medicine, Soonchunhyang University, Cheonan, Korea.ORCID https://orcid.org/0000-0002-5484-380X
Seul-Gi LeeCollege of Veterinary Medicine, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0009-0006-9396-8222
C-Yoon KimCollege of Veterinary Medicine, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0000-0003-1199-8024
Hyung Min ChungDepartment of Stem Cell Biology, School of Medicine, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0000-0002-9686-5695

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prime editing (PE) is a recently developed genome-editing technique that enables versatile editing. Despite its flexibility and potential, applying PE in human induced pluripotent stem cells (hiPSCs) has not been extensively addressed. Genetic disease models using patient-derived hiPSCs have been used to study mechanisms and drug efficacy. However, genetic differences between patient and control cells have been attributed to the inaccuracy of the disease model, highlighting the significance of isogenic hiPSC models. Hereditary hemorrhagic telangiectasia 1 (HHT1) is a genetic disorder caused by an autosomal dominant mutation in endoglin (

Indexed as

EndoglinGene editingGenetic diseasesHereditary hemorrhagic telangiectasiaInduced pluripotent stem cells

Identifiers

PMID39238188
PMCPMC11612218

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.