Evidence map›Paper›PMID 39238641›Full record

ArticleFrontiers in immunology2024

SARS-CoV-2 spike protein antibody titers after the fourth dose of BNT162b2 vaccine among Japanese patients undergoing hemodialysis: a single-center study.

Shun Watanabe, Toyoaki Sawano, Hiroaki Saito, Akihiko Ozaki, Masatoshi Wakui, Tianchen Zhao, Chika Yamamoto, Yurie Kobashi, Takeshi Kawamura, Akira Sugiyama and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shun WatanabeDepartment of Urology, Jyoban Hospital of Tokiwa Foundation, Iwaki, Fukushima, Japan.
Toyoaki SawanoDepartment of Surgery, Jyoban Hospital of Tokiwa Foundation, Iwaki, Fukushima, Japan.
Hiroaki SaitoDepartment of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
Akihiko OzakiBreast and Thyroid Center, Jyoban Hospital of Tokiwa Foundation, Iwaki, Fukushima, Japan.
Masatoshi WakuiDepartment of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan.
Tianchen ZhaoDepartment of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
Chika YamamotoDepartment of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
Yurie KobashiDepartment of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
Takeshi KawamuraIsotope Science Center, The University of Tokyo, Tokyo, Japan.
Akira SugiyamaIsotope Science Center, The University of Tokyo, Tokyo, Japan.
Aya NakayamaIsotope Science Center, The University of Tokyo, Tokyo, Japan.
Yudai KanekoLaboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Hiroaki ShimmuraDepartment of Urology, Jyoban Hospital of Tokiwa Foundation, Iwaki, Fukushima, Japan.
Masaharu TsubokuraDepartment of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients undergoing hemodialysis are particularly vulnerable to severe outcomes of SARS-CoV-2 infection, with mortality rates higher than that of the general population. Vaccination reduces the risk of adverse outcomes, with booster doses being particularly beneficial. However, limited data are available on the effectiveness of subsequent vaccinations or their effect on increasing antibody levels. This single-center study aimed to investigate changes in SARS-CoV-2 IgG antibody titers following the fourth vaccination among 28 patients undergoing hemodialysis. Blood tests were conducted at various intervals post-vaccination, with a focus on identifying factors associated with antibody levels. The IgG antibody levels rapidly increased by Day 7 post-vaccination, with a median time to peak of 11 days. Antibody titers tended to be higher in male patients than in female patients. This study sheds light on the immune response to the fourth vaccination in patients undergoing hemodialysis. As this study included a small sample size, with a short observation period, further research is warranted to comprehensively understand the effectiveness of vaccination and the benefits of additional doses of vaccine.

Indexed as

Antibodies, ViralBNT162 VaccineCOVID-19Immunoglobulin GRenal DialysisAgedEast Asian PeopleFemaleHumansImmunization, SecondaryJapanMaleMiddle AgedSpike Glycoprotein, CoronavirusVaccinationAntibodies, ViralBNT162 VaccineImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2BNT162b2 vaccinechronic kidney failurefourth dose of vaccinehemodialysisIgG antibody titersSARS-CoV-2

Identifiers

PMID39238641
PMCPMC11375752

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.