Evidence map›Paper›PMID 39238643›Full record

ArticleFrontiers in immunology2024

Functional evaluation of rare variants in complement factor I using a minigene assay.

Cobey J H Donelson, Nicolo Ghiringhelli Borsa, Amanda O Taylor, Richard J H Smith, Yuzhou Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cobey J H DonelsonMolecular Otolaryngology and Renal Research Laboratory, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Nicolo Ghiringhelli BorsaMolecular Otolaryngology and Renal Research Laboratory, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Amanda O TaylorMolecular Otolaryngology and Renal Research Laboratory, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Richard J H SmithMolecular Otolaryngology and Renal Research Laboratory, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Yuzhou ZhangMolecular Otolaryngology and Renal Research Laboratory, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.

Funding

C3 Glomerulopathy -- A Collaborative StudyR01DK110023 · NIDDK · UNIVERSITY OF IOWA · PI Patrick Breheny, Carla M Nester · 2017 to 2026
$5.6M
NIDDK NIH HHS R01 DK110023
6 · The paper itself

Abstract

The regulatory serine protease, complement factor I (FI), in conjunction with one of its cofactors (FH, C4BP, MCP, or CR1), plays an essential role in controlling complement activity through inactivation of C3b and C4b. The functional impact by missense variants in the

Indexed as

Complement Factor IFemaleGene FrequencyGenetic VariationHumansMaleMutation, MissenseRNA SplicingCFI protein, humanComplement Factor Ialternative pathwayCis/trans-acting elementscomplementcomplement factor Icomplement-mediated diseaseshaploinsufficiencyRNA splicing

Identifiers

PMID39238643
PMCPMC11374653

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.