ArticleJACC. Advances2024
Anxiety and Depression Associated With Increased Cardiovascular Disease Risk Through Accelerated Development of Risk Factors.
Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis.Molecular psychiatry · 2025Pooled it
- Psychic and Cognitive Impacts of Cardiovascular Disease: Evidence from an Observational Study and Comparison by a Systematic Literature Review.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Vitamin D and Health: Establishing Causal Relationships Through Observational Evidence and Hill's Criteria in a Biological Framework.Nutrients · 2026Review
- Longitudinal Associations of Cumulative Depression Burden With Cardiovascular Diseases and All-Cause Death Among Middle-Aged and Older Population: Evidence From 2 Nationwide Cohort Studies.Journal of the American Heart Association · 2026Article
- Anxiety and Depression in Women's Cardiovascular Health: Risk Modifiers, Mechanisms and Clinical Implications.Journal of cardiovascular development and disease · 2026Review
- Psychological Health, Polysocial Risk, and Cardiovascular Health Among Women of Reproductive Age.JACC. Advances · 2026Article
- Symptom-specific intervention targets for depression and anxiety among older adults by physical multimorbidity patterns: a simulation-based network analysis.Social psychiatry and psychiatric epidemiology · 2026Article
- Depression, Anxiety, and Bipolar Disorder and Atherosclerosis.Current atherosclerosis reports · 2026Review
- Bidirectional brain-heart interactions in health and disease.Nature reviews. Neurology · 2026Review
- The Mental Health-Acute Coronary Syndrome Continuum: Bidirectional Pathophysiological Links and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
- The Effect of Tooth Loss on Depression and Anxiety Among Older Adults in China: The Mediating Role of Dietary Diversity.Nutrients · 2026Article
- Emotion regulation habits and emotional states of college students during lockdown: A cross-sectional survey.World journal of psychiatry · 2026Article
- Association of thyroid nodules with comorbidity burden and prognosis in patients with heart failure, anemia, and hyperuricemia: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Exploratory prescribing risk profiles and drug drug interaction burden in older adults with depressive episodes.Frontiers in psychiatry · 2026Article
- The effectiveness of eHealth-based cardiovascular disease risk communication: a systematic review and meta-analysis.NPJ digital medicine · 2025Article
- Predicting patient-related outcomes after atrial fibrillation ablation: insights from explainable artificial intelligence and digital health.European heart journal. Digital health · 2025Article
- The mediating role of biological age in the impact of mood instability symptoms on neurodegenerative disease and mortality.BMC medicine · 2025Article
- Post-Myocardial Infarction Psychological Distress: A Scientific Statement From the American Heart Association.Circulation · 2025Review
- Panic Attack Prediction for Patients With Panic Disorder via Machine Learning and Wearable Electrocardiography Monitoring: Model Development and Validation Study.Journal of medical Internet research · 2025Article
- Integrating Emotional Stress and Lipid Lowering in Cardiovascular Disease Management: The Future of Precision Cardiovascular Prevention.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
Background: Prior studies have incompletely assessed whether the development of cardiometabolic risk factors (CVDRF) (hypertension, hyperlipidemia, and diabetes mellitus) mediates the association between anxiety and depression (anxiety/depression) and cardiovascular disease (CVD). Objectives: The authors aimed to evaluate the following: 1) the association between anxiety/depression and incident CVDRFs and whether this association mediates the increased CVD risk; and 2) whether neuro-immune mechanisms and age and sex effects may be involved. Methods: Using a retrospective cohort design, Mass General Brigham Biobank subjects were followed for 10 years. Presence and timing of anxiety/depression, CVDRFs, and CVD were determined using ICD codes. Stress-related neural activity, chronic inflammation, and autonomic function were measured by the assessment of amygdalar-to-cortical activity ratio, high-sensitivity CRP, and heart rate variability. Multivariable regression and mediation analyses were employed. Results: Among 71,214 subjects (median age 49.6 years; 55.3% female), 27,048 (38.0%) developed CVDRFs during follow-up. Pre-existing anxiety/depression associated with increased risk of incident CVDRF (OR: 1.71 [95% CI: 1.59-1.83], Conclusions: Anxiety/depression accelerate the development of CVDRFs. This association appears to be most notable among younger women and may be mediated by stress-related neuro-immune pathways. Evaluations of tailored preventive measures for individuals with anxiety/depression are needed to reduce CVD risk.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.