Evidence map›Paper›PMID 39239032›Full record

ArticleAnnals of medicine and surgery (2012)2024

Chemical burn wounds as a risk factor for gastric cancer: in-silico analyses-experimental research.

Mohammad Reza Zabihi, Mohammad Akhoondian, Mobina Tohidian, Samad Karkhah, Pooyan Ghorbani Vajargah, Seyed Amirhossein Mazhari, Bahar Farhadi, Ramyar Farzan

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In one paragraph

Article in Annals of medicine and surgery (2012), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad Reza ZabihiDepartment of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran.
Mohammad AkhoondianDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University.
Mobina TohidianDepartment of Anatomy and Cell Biology, Shahi Beheshti University of Medical Sciences, Tehran.
Samad KarkhahDepartment of Medical-Surgical Nursing, School of Nursing and Midwifery.
Pooyan Ghorbani VajargahDepartment of Medical-Surgical Nursing, School of Nursing and Midwifery.
Seyed Amirhossein MazhariStudent Research Committee, Azerbaijan Medical University, Baku, Azerbaijan.
Bahar FarhadiSchool of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran.
Ramyar FarzanDepartment of Plastic & Reconstructive Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The present study employs bioinformatics tools to identify shared upregulated genes between chemical burns and gastric cancer. Methods: Gene Expression Omnibus (GEO) retrieved gene sets for this investigation. GSEs with Results: In the present study, two genes, including ALOX5AP and SERPINB2, were obtained, with the highest centrality among chemical burns and gastric cancer shared genes. Additionally, the current study presented five drugs, including Urokinase, Tenecteplase, DG031, AM103, and Fiboflapon, which can have predicted effects on gastric cancer following chemical burns. Conclusion: According to current in-silicon analyses, ALOX5AP and SERPINB2 are linked genetic keys between gastric chemical burn and cancer. Considering that burn is an environmental factor that leads to the upregulation of the two genes thus, the chemical burn can be related to the incidence of gastric cancer.

Indexed as

burnscancerchemical burnsgastric cancerwounds

Identifiers

PMID39239032
PMCPMC11374194

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.