Evidence map›Paper›PMID 39243174›Full record

ArticleOrthopaedic surgery2024

Combining Tibial Cortex Transverse Transport (TTT) and Endovascular Therapy (EVT) for Limb Salvage in Chronic Limb-Threatening Ischemia.

Yi Ding, Dapeng Yu, Haoheng Huang, Xiao Peng, Shenghui Yang, Zhanming Lin, Peiling Zhou, Jilin Liang, Xiaochong Zou, Ruiqing Mo and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07444593 (SMILE - TTT), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07444593 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

SMILE - TTT: Surgical MIcrovascularization of Lower Extremities for Diabetic Foot Ulcers - Transverse Tibial Transport Study

TypeinterventionalSponsorBiodynamik, IncRan2026 to 2027Enrolled100ConditionsDiabetic Foot Ulcer, Chronic Ulcers of the Lower LimbArmsBiodynamik XT3
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. [Research advances in limb salvage treatment of diabetic foot using tibial transverse transport].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Pooled it
  2. Tibial Osteodistraction Angiogenesis for Diabetic Foot Ischemia: A Systematic Review and Meta-Analysis.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Pooled it
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yi DingDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Dapeng YuDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Haoheng HuangDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xiao PengDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Shenghui YangDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhanming LinDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Peiling ZhouDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jilin LiangDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xiaochong ZouDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Ruiqing MoDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Kaixiang PanDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Puxiang ZhengDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xiaocong KuangGuangxi Diabetic Foot Salvage Engineering Research Center, Nanning, China.
Xinyu NieGuangxi Diabetic Foot Salvage Engineering Research Center, Nanning, China.
Qikai HuaDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.ORCID https://orcid.org/0000-0001-5101-6115

Funding

Clinical Research Climbing Plan of the First Affiliated Hospital of Guangxi Medical University YYZS2020010Guangxi Key Research and Development Program 2021AB11027Key Research and Development Plan of Qingxiu District, Nanning City 2020053National Natural Science Foundation of China 82260448
6 · The paper itself

Abstract

objectiveThe clinical management of patients with chronic limb-threatening ischemia (CLTI) faces great challenges. Enhancing wound healing and limb preservation rates in this cohort is a critical objective. This study investigates the effectiveness of combining tibial cortex transverse transport (TTT) and endovascular therapy (EVT) for the treatment of patients with severe CLTI. We aim to evaluate the therapeutic results of this combined approach on the specified patient group.

methodsWe conducted a retrospective study to compare EVT with the combination of TTT and EVT in patients (Rutherford category 5 and above) with CLTI at Guangxi Medical University's First Affiliated Hospital from June 2017 to June 2023. This cohort was subjected to a follow-up period ranging from a minimum of 6 months to a maximum of 12 months. The primary outcome measures included amputation-free survival (AFS) (avoidance of above-ankle amputation or death from any cause), overall mortality, limb salvage rates, wound healing efficiency, and the technical efficacy of the applied treatments. A variety of statistical analyses including chi-square tests, Fisher's exact tests, and Pearson's and Spearman's correlation analyses.

resultsIn this study, 131 patients with CLTI were included: 76 in the control group receiving only EVT treatment and 55 in the TTT + EVT group. The two groups were matched on demographic and clinical characteristics. In the TTT + EVT group, after more than 6 months of follow-up, 85.5% of patients achieved AFS, and wound healing was observed in 54.5% (30 of 55 patients). After more than 12 months of follow-up, 81.9% achieved AFS, with wound healing in 32 patients. Furthermore, after more than 24 months, 74.2% of patients remained amputation-free, with wound healing in all surviving patients. In the control group, after more than 6 months of follow-up, 72.4% of patients achieved AFS, and wound healing was observed in 51.3% (39 of 96 patients). After more than 12 months, 48.9% achieved AFS, with wound healing in 21 patients.

conclusionWe found that combining therapy of TTT and EVT is safe and can be successfully administered in patients with CLTI and it enhances wound healing and AFS.

Indexed as

Endovascular ProceduresLimb SalvageAgedAged, 80 and overChronic Limb-Threatening IschemiaCombined Modality TherapyFemaleHumansIschemiaMaleMiddle AgedRetrospective StudiesTibiaChronic Limb‐Threatening IschemiaEndovascular TherapyLimb SalvageTibial Cortex Transverse Transport

Identifiers

PMID39243174
PMCPMC11572561

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.