Evidence map›Paper›PMID 39244689›Full record

ArticleCell biochemistry and biophysics2025

HMGA1 Regulates IRS2 to Promote Inflammatory Responses and Oxidative Stress Injury in MPP

Dongxun Xu, Wenhui Fan, Bing Fu, Hongxia Nie

Abstract read
PubMed Publisher
In one paragraph

Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dongxun XuDepartment of Neurology, Sichuan Taikang Hospital, Chengdu, 610213, Sichuan Province, P. R. China.
Wenhui FanDepartment of Neurology, Sichuan Taikang Hospital, Chengdu, 610213, Sichuan Province, P. R. China.
Bing FuDepartment of Neurology, The Second People's Hospital of Lianyungang, Lianyungang, 222006, Jiangsu Province, P. R. China.
Hongxia NieDepartment of Neurology, The Second People's Hospital of Lianyungang, Lianyungang, 222006, Jiangsu Province, P. R. China. niehongxia_nhx@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a prevalent neurodegenerative disorder for which novel treatment approaches are continuously sought. This study investigates the role of high-mobility group A1 (HMGA1) in modulating inflammatory responses and oxidative stress injury in PD. We utilized the murine dopaminergic neuronal cell line MN9D, treating cells with 1-methyl-4-phenylpyridinium ion (MPP

Indexed as

1-Methyl-4-phenylpyridiniumHMGA1a ProteinInflammationInsulin Receptor Substrate ProteinsOxidative StressAnimalsCell LineCell SurvivalMiceReactive Oxygen Species1-Methyl-4-phenylpyridiniumHMGA1a ProteinInsulin Receptor Substrate ProteinsIrs2 protein, mouseReactive Oxygen SpeciesHMGA1IRS2MPP+Oxidative stressParkinson’s disease

Identifiers

PMID39244689

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.