Evidence map›Paper›PMID 39245327›Full record

ReviewInternational journal of antimicrobial agents2024

Past, present, and future biomarkers of kidney function and injury: The relationship with antibiotics.

Jack Chang, Gwendolyn M Pais, Erin F Barreto, Bryce Young, Haley Scott, Zachary Schwartz, Collin Cartwright, Raymond Jubrail, Anand Srivastava, Marc H Scheetz

Abstract readReview
In one paragraph

Review in International journal of antimicrobial agents, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jack ChangDepartment of Pharmacy Practice (J.C., G.M.P., R.J., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA; Pharmacometrics Center of Excellence (J.C., G.M.P., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA; Department of Pharmacy (J.C., M.H.S.), Northwestern Memorial Hospital, Chicago, Illinois, USA.
Gwendolyn M PaisDepartment of Pharmacy Practice (J.C., G.M.P., R.J., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA; Pharmacometrics Center of Excellence (J.C., G.M.P., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA.
Erin F BarretoDepartment of Pharmacy (E.F.B.), Mayo Clinic, Rochester, Minnesota, USA.
Bryce YoungChicago College of Osteopathic Medicine (B.Y., H.S., Z.S., C.C.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA.
Haley ScottChicago College of Osteopathic Medicine (B.Y., H.S., Z.S., C.C.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA.
Zachary SchwartzChicago College of Osteopathic Medicine (B.Y., H.S., Z.S., C.C.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA.
Collin CartwrightChicago College of Osteopathic Medicine (B.Y., H.S., Z.S., C.C.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA.
Raymond JubrailDepartment of Pharmacy Practice (J.C., G.M.P., R.J., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA.
Anand SrivastavaDivision of Nephrology (A.S.), University of Illinois-Chicago, Chicago, Illinois, USA.
Marc H ScheetzDepartment of Pharmacy Practice (J.C., G.M.P., R.J., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA; Pharmacometrics Center of Excellence (J.C., G.M.P., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA; Department of Pharmacy (J.C., M.H.S.), Northwestern Memorial Hospital, Chicago, Illinois, USA; Department of Pharmacology (M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA. Electronic address: mschee@midwestern.edu.

Funding

Non-Invasive Imaging Biomarkers to Identify a High-Risk Chronic Kidney Disease PhenotypeK23DK120811 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SRIVASTAVA, ANAND · 2020 to 2024
$1.0M
Beta-lactam individualization for critically ill patientsK23AI143882 · NIAID · MAYO CLINIC ROCHESTER · PI BARRETO, ERIN FRAZEE · 2020 to 2024
$986k
NIAID NIH HHS K23 AI143882NIDDK NIH HHS K23 DK120811
6 · The paper itself

Abstract

Routinely used kidney biomarkers of injury and function such as serum creatinine and urine albumin to creatinine ratio, are neither sensitive nor specific. Future biomarkers are being developed for clinical use and have already been included in guidance from groups such as the U.S. Food and Drug Administration and the Predictive Safety Testing Consortium. These biomarkers have important implications for early identification of kidney injury and more accurate measurement of kidney function. Many antibiotics are either eliminated by the kidney or can cause clinically significant nephrotoxicity. As a result, clinicians should be familiar with new biomarkers of kidney function and injury, their place in clinical practice, and applications for antibiotic dosing.

Indexed as

Anti-Bacterial AgentsBiomarkersAcute Kidney InjuryCreatinineHumansKidneyKidney Function TestsAnti-Bacterial AgentsBiomarkersCreatinineAntibioticsBiomarkersInjuryKidney function

Identifiers

PMID39245327
PMCPMC12617295

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.