A Rare Case of Richter Transformation to Both Clonally Unrelated and Clonally Related Diffuse Large B-Cell Lymphoma in the Same Patient.

Michelle D Don, Carlos Casiano, Huan-You Wang, Mikhail Gorbounov, Wei Song, Edward D Ball

Abstract readCase Reports

In one paragraph

Article in Case reports in hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

Chronic lymphocytic leukemia often arises by a multiclonal selection process.Haematologica · 2025
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Authors and funding

6 authors.

Michelle D DonDivision of Laboratory and Genomic Medicine Department of Pathology University of California San Diego, 3855 Health Sciences Drive Room 3074, La Jolla, San Diego 92093, CA, USA.ORCID https://orcid.org/0000-0001-5167-0926

Carlos CasianoDivision of Laboratory and Genomic Medicine Department of Pathology University of California San Diego, 3855 Health Sciences Drive Room 3074, La Jolla, San Diego 92093, CA, USA.

Huan-You WangDivision of Laboratory and Genomic Medicine Department of Pathology University of California San Diego, 3855 Health Sciences Drive Room 3074, La Jolla, San Diego 92093, CA, USA.

Mikhail GorbounovDivision of Laboratory and Genomic Medicine Department of Pathology University of California San Diego, 3855 Health Sciences Drive Room 3074, La Jolla, San Diego 92093, CA, USA.ORCID https://orcid.org/0000-0001-6236-0341

Wei SongDivision of Laboratory and Genomic Medicine Department of Pathology University of California San Diego, 3855 Health Sciences Drive Room 3074, La Jolla, San Diego 92093, CA, USA.

Edward D BallDivision of Blood and Marrow Transplant Department of Medicine University of California San Diego, 3855 Health Sciences Drive, La Jolla, San Diego 92093, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Richter transformation (RT) is a rare sequelae of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The clonal relationship of the RT to the underlined CLL/SLL is an important prognostic factor as clonally related RT has a worse prognosis than that of clonally unrelated RT. The development of more than one RT in the same patient is exceedingly rare and prior reports have shown cases consisting of RT to diffuse large B-cell lymphoma (DLBCL) and a subsequent or synchronous Hodgkin lymphoma. Here, we present a rare case of RT first to a clonally unrelated DLBCL and subsequently a clonally related DLBCL. Additionally, we retrospectively conducted next-generation sequencing studies of both RT's and found different mutational landscapes, including more clinically aggressive mutations identified in the clonally related RT. To our knowledge, this is the first reported case of clonally related and clonally unrelated RT, both of which are DLBCL, in the same patient.

Identifiers

PMID39246801

DOI10.1155/2024/7913296

PMCPMC11380716

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