ReviewCureus2024
Lactate Monitoring in Intensive Care: A Comprehensive Review of Its Utility and Interpretation.
Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High-Risk Factors of In-Hospital Death Following Complex High-risk and Indicated Patients After Percutaneous Coronary Intervention Supported by Extracorporeal Membrane Oxygenation.Reviews in cardiovascular medicine · 2025Pooled it
- Comparative Outcomes of Nurse-Led Early Mobilization Versus Standard Care in Acute Pancreatitis: A Randomized Controlled Trial.Digestive diseases and sciences · 2026Trial
- Advancements in early biomarkers of acute kidney injury: from traditional indicators to a paradigm shift in lactate metabolism.Annals of medicine · 2026Review
- Rapid Treatment of Acute Decompensated Heart Failure with Cardiogenic Shock in the Emergency Setting.Cardiology and cardiovascular medicine · 2026Article
- Beyond Fluid Responsiveness: Why Venous Congestion Matters in Sepsis.Current medical science · 2026Article
- Prognostic Value of the Lactate-to-Albumin and C-Reactive Protein-to-Albumin Ratios in COVID-19-Associated ARDS.Journal of clinical medicine · 2026Article
- The molecular ICU: a primer on omics, informatics and the future of precision critical care.Critical care (London, England) · 2026Review
- Association between the lactate-to-albumin ratio and mortality in patients with protein-energy malnutrition: a retrospective cohort study.BMC nutrition · 2026Article
- Carboxyhemoglobin tracks acute arterial desaturation in healthy volunteers: a pooled analysis of four controlled desaturation studies.Scientific reports · 2026Article
- The relationship between lactate-to-albumin ratio and prognosis in patients with sepsis-induced cardiomyopathy: a retrospective cohort study.Scientific reports · 2026Article
- Compact mid-infrared fiber probe for in vivo multi-compound monitoring demonstrated using ex vivo human skin.Nature communications · 2026Article
- Sepsis and the immunometabolic inflammatory response.npj metabolic health and disease · 2026Review
- Association between lactate-to-albumin ratio and clinical outcomes in perioperative patients with chronic kidney disease: a retrospective cohort study based on INSPIRE database.Clinical and experimental nephrology · 2026Article
- Perioperative Blood Biomarkers of Infectious and Non-Infectious Postoperative Pulmonary Complications: A Narrative Review.Journal of clinical medicine · 2026Review
- Developing and validating a lactate-to-albumin ratio-enhanced score for mortality prediction in ICU patients with acute pulmonary embolism: a multi-cohort study.Frontiers in medicine · 2026Article
- Effects of Initial Lactate Levels and 24-h Lactate Clearance on Mortality in Post-Cardiac Arrest Patients: Insights from the Multicenter TIMECARD Registry.International journal of medical sciences · 2026Article
- Safety recommendations on laboratory and blood count values for early mobilization in critically ill adults: an expert consensus.Critical care science · 2026Article
- Acute gastrointestinal injury in children on ECMO: an analysis of risk factors.Frontiers in medicine · 2026Article
- Beyond antimicrobials: a host-directed precision pharmacotherapy framework for septic shock.Frontiers in medicine · 2026Article
- Intraoperative peak lactate as a predictor of in-hospital mortality following non-cardiac emergency surgery: a retrospective cohort study.Langenbeck's archives of surgery · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactate monitoring is critical in managing critically ill patients in intensive care settings. Elevated lactate levels often signify underlying metabolic disturbances such as tissue hypoxia, anaerobic metabolism, or impaired lactate clearance, which are prevalent in conditions like sepsis, shock, and trauma. Understanding the physiological basis of lactate production and its significance in clinical practice is essential for interpreting its diagnostic and prognostic value. This comprehensive review aims to explore the utility of lactate monitoring across various critical care scenarios. It provides an overview of lactate's metabolic pathways, methods of measurement, and the clinical implications of interpreting lactate levels in different contexts. Additionally, the review discusses current evidence on lactate-guided therapeutic interventions and highlights challenges and limitations to their application. By synthesizing the existing literature and clinical insights, this review aims to enhance the understanding of the role of lactate monitoring in assessing disease severity, guiding treatment strategies, and predicting outcomes in critically ill patients. Ultimately, this review underscores the importance of integrating lactate monitoring into routine clinical practice to optimize patient care and improve clinical outcomes in intensive care settings.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.