Evidence map›Paper›PMID 39248455›Full record

ArticleCNS neuroscience & therapeutics2024

Delineating structural and metabolic abnormalities in amygdala and hippocampal subfields for different seizure-onset patterns via stereotactic electroencephalography.

Tao Feng, Yanfeng Yang, Yihe Wang, Peng-Hu Wei, Xiaotong Fan, Huaqiang Zhang, Yang An, Tianren Wang, Yuda Huang, Sichang Chen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tao FengDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yanfeng YangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yihe WangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Peng-Hu WeiDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-4529-7691
Xiaotong FanDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Huaqiang ZhangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yang AnDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Tianren WangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yuda HuangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Sichang ChenDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yueshan PiaoChina International Neuroscience Institute (CHINA-INI), Beijing, China.
Fenglai XiaoDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
John S DuncanDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Yongzhi ShanDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-5510-1026
Guoguang ZhaoDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Funding

Beijing Municipal Health Commission 11000022T000000444685Beijing Municipal Health Commission 11000023T000002036286National Key R&D Program of China 2021ZD0201801National Natural Science Foundation of China 82030037
6 · The paper itself

Abstract

aimsWe aimed to investigate mesial temporal lobe abnormalities in mesial temporal lobe epilepsy (MTLE) patients with hypersynchronous (HYP) and low-voltage fast rhythms (LVF) onset identified by stereotactic electroencephalography (SEEG) and evaluate their diagnostic and prognostic value.

methodsFifty-one MTLE patients were categorized as HYP or LVF by SEEG. High-resolution MRI volume-based analysis and

resultsLVF-onset individuals demonstrated ipsilateral amygdala enlargement (p = 0.048) and contralateral hippocampus hypermetabolism (p = 0.042), pathological results often accompany abnormalities in the temporal lobe cortex, while HYP-onset subjects had significant atrophy (p < 0.001) and hypometabolism (p = 0.013) in ipsilateral hippocampus and its subfields, as well as amygdala atrophy (p < 0.001), pathological results are highly correlated with hippocampal sclerosis. Severe fimbria atrophy was observed in cases of HYP-onset MTLE with poor prognosis (AUC = 0.874).

conclusionIndividuals with different seizure-onset patterns display specific morphological and metabolic abnormalities in the amygdala and hippocampus. Identifying these subfield abnormalities can improve diagnostic and prognostic precision, guiding surgical strategies for MTLE.

Indexed as

AmygdalaElectroencephalographyEpilepsy, Temporal LobeHippocampusMagnetic Resonance ImagingPositron-Emission TomographyStereotaxic TechniquesAdultFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedSeizuresYoung AdultFluorodeoxyglucose F18amygdalahippocampusseizure onset patternsstereotactic electroencephalographytemporal lobe epilepsy

Identifiers

PMID39248455
PMCPMC11382356

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.