Evidence map›Paper›PMID 39248576›Full record

ArticleNeuro-oncology2025

Cognitive phenotypes: Unraveling the heterogeneity in cognitive dysfunction among patients with primary brain tumors receiving radiotherapy.

Anny Reyes, Alena Stasenko, Austin Hopper, Jiwandeep S Kohli, Jonathan L Helm, Mia Salans, Divya Prabhakaran, Lily Kamalyan, Molly Wilkinson, Soumya Unnikrishnan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anny ReyesDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0003-0625-6990
Alena StasenkoDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Austin HopperDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA.
Jiwandeep S KohliDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA.
Jonathan L HelmDepartment of Psychology, San Diego State University, San Diego, California, USA.
Mia SalansDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California, USA.
Divya PrabhakaranDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA.
Lily KamalyanSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA.ORCID 0000-0002-3099-0549
Molly WilkinsonSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA.
Soumya UnnikrishnanDepartment of Radiation Oncology, Emory University, Atlanta, Georgia, USA.
Roshan KarunamuniDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA.
Jona Hattangadi-GluthDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0001-8222-606X
Carrie R McDonaldDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.

Funding

San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
BRain Aging and Cognition in Epilepsy (BRACE): A longitudinal investigationof vascular, genetic, and biomarker risk profiles in elderly patients with epilepsyR01NS120976 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$4.1M
UC San Diego Clinical and Translational Research InstituteTL1TR001443 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2019
$3.4M
Mechanisms of Radiation-Induced Neurocognitive Decline (MIND): Longitudinal Study of Imaging Biomarkers and Risk and Resilience Factors Underlying Cognitive Phenotypes in Patients with GliomaR01CA289833 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jona A Hattangadi-Gluth, CARRIE R MCDONALD · 2025 to 2026
$1.3M
Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases: Avoidance of Eloquent White Matter and Hippocampal RegionsR01CA238783 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HATTANGADI-GLUTH, JONA A · 2019 to 2021
$737k
Improving language assessment in bilinguals with epilepsy using advanced neuroimaging and culturally-sensitive neuropsychological measuresF32NS119285 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STASENKO, ALENA · 2021 to 2023
$152k
American Cancer Society RSG-15-229-01-CCEBurroughs Wellcome Fund Postdoctoral Diversity Enrichment ProgramHSRD VA TPR 15-229National Academy of Neuropsychology Clinical ResearchNCATS NIH HHS KL2 TR001444NCATS NIH HHS TL1 TR001443NCATS NIH HHS UL1 TR000100NCI NIH HHS R01 CA238783NCI NIH HHS R01 CA289833NIH HHS 1KL2TR001444NIMH NIH HHS T32 MH018399NINDS NIH HHS F32 NS119285NINDS NIH HHS R01 NS120976
6 · The paper itself

Abstract

backgroundPatients with primary brain tumors demonstrate heterogeneous patterns of cognitive dysfunction, which we explore using latent profile analysis to identify cognitive phenotypes and their trajectories in patients receiving radiotherapy (RT).

methodsNinety-six patients completed neuropsychological testing before and post-RT (3, 6, and 12 months) on a prospective longitudinal trial, including measures of processing speed, executive function, language, and verbal and visual memory. Models with 2-4 classes were examined. Demographic and clinical data were examined across phenotypes and post-RT cognitive change was evaluated.

resultsThe optimal model identified 3 unique cognitive phenotypes including a group of patients with generalized impairments (11.5%), a group with isolated verbal memory impairments (21.9%), and a group with minimal impairments (66.7%). The Verbal Memory phenotype had fewer years of education (P = .007) and a greater proportion of males (P < .001); the Generalized group had a greater proportion of patients with IDH-wild type gliomas and showed greater symptoms of anxiety and poorer quality of life (P-values < .05); and the Minimal Impairment phenotype had higher rates of IDH-Mutant gliomas. Approximately 50% of patients declined on at least one cognitive domain with memory being the most vulnerable. Patients who declined reported greater symptoms of depression (P = .007) and poorer quality of life (P = .025).

conclusionsWe identified 3 distinct cognitive phenotypes in patients with primary brain tumors receiving RT, each associated with unique demographic and clinical (eg, IDH mutational status) profiles, with mood symptoms associated with late cognitive decline. This patient-centered approach enhances our understanding of clinical profiles associated with cognitive dysfunction and treatment-related neurotoxicity.

Indexed as

Brain NeoplasmsCognitive DysfunctionGliomaAdultAgedFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsPhenotypePrognosisProspective StudiesQuality of Lifecognitive declinememoryneurotoxicitypatient-centeredphenotypes

Identifiers

PMID39248576
PMCPMC11812028

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.