ArticleCerebrovascular diseases (Basel, Switzerland)2025
High Resting Heart Rate Is Associated with Cardiovascular Death in Patients with Stroke, Independent of Sex.
Article in Cerebrovascular diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Integrative Multidimensional Machine Learning Models for Stroke Prognosis: Age-Stratified and History Engineered Perspectives.Diagnostics (Basel, Switzerland) · 2026Article
- Leg-fidgeting versus standing breaks during prolonged sitting: Impacts on blood pressure and heart rate in young women.Experimental physiology · 2025Article
- Prognostic impact of collateral circulation in direct thrombectomy versus bridging thrombectomy for acute ischemic stroke patients with anterior circulation large vessel occlusion: a retrospective comparative study.Frontiers in neuroscience · 2025Article
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Authors and funding
6 authors.
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Abstract
introductionHigh resting heart rate (HRHR) is a surrogate marker of increased sympathetic outflow. In acute stroke patients, HRHR is more commonly observed in women than in men. We analyzed whether HRHR (>86 bpm) adds incremental prognostic value for stroke outcomes in women.
methodsWe analyzed data of 6,024 patients (2,568 women, mean age 68.98 years) with acute ischemic stroke from the Virtual International Stroke Trials Archive (VISTA).
resultsPatients with HRHR were more often female (45.3 vs. 41.8%, p = 0.017), younger (66.0 ± 13.2 vs. 67.8 ± 12.6 years, p < 0.001), had higher baseline systolic blood pressure and more often diabetes. The primary composite endpoint of recurrent ischemic stroke, transient ischemic attack, myocardial infarction, or cardiovascular death within 90 days occurred more often in patients with HRHR (19.3 vs. 14.6%, p < 0.001). HRHR was associated with worse functional outcome at 90 days as assessed by modified Rankin Scale (mRS90: 3.03 ± 1.98 vs. 2.82 ± 1.94, p = 0.001). As exclusion of deceased patients (mRS90 of 6) resulted in a loss of association of HRHR with mRS90, it can be assumed that HRHR is mainly associated with poststroke vascular mortality, but not disability. Female sex was not associated with the primary endpoint but with adverse functional outcome measured by mRS90.
conclusionHRHR was associated with adverse events and mortality after stroke. Despite a higher prevalence of HRHR in women, they did not reach the primary endpoint more often. However, women had a worse functional outcome (mRS) 3 months after stroke, independent of HRHR.
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