ArticleNature communications2024
Propofol disrupts the functional core-matrix architecture of the thalamus in humans.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping fMRI research in disorders of consciousness: a bibliometric study.Frontiers in neurologyPooled it
- Thalamic Nuclei Atrophy in Type 1 Diabetes Mellitus Across Disease Duration.Journal of magnetic resonance imaging : JMRI · 2026Article
- Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble.bioRxiv : the preprint server for biology · 2026Article
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- Opposite network patterns of integration-segregation in psychedelic and sedated states of consciousness.Cell reports · 2026Article
- Advances in local field potential research in prolonged disorders of consciousness: a narrative review.Chinese neurosurgical journal · 2026Review
- Reorganization of Human Brain Waves Across Diverse States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- Adversarial AI reveals mechanisms and treatments for disorders of consciousness.Nature neuroscience · 2026Article
- Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains.Nature human behaviour · 2026Article
- Opposing Network Patterns of Integration-Segregation in Psychedelic and Sedated States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- Neurophysiological connectomic signatures of consciousness during propofol-induced general anesthesia.Cell reports. Medicine · 2026Article
- A dopaminergic projection from the ventral tegmental area to the dorsal raphe nucleus critically regulates propofol anesthesia in mice.Biology direct · 2026Article
- Heightened propofol sensitivity and distinct electroencephalographic signatures in patients with valvular heart disease.BMC anesthesiology · 2026Observational
- A thalamic perspective of (un)consciousness in pharmacological and pathological states in humans.Brain communications · 2026Article
- Corticothalamic dynamics during postictal recovery of self-orientation after electroconvulsive therapy.Brain communications · 2026Article
- Immediate large-scale cortical network changes following acupuncture in patients with disorders of consciousness: a resting-state fNIRS study.Frontiers in neuroscience · 2026Article
- Neural Circuit Mechanisms of General Anaesthesia Induction: Current Advances and Future Directions.Current neuropharmacology · 2026Review
- Differential engagement of thalamic nuclei orchestrates consciousness states across anesthesia, sleep, and disorders of consciousness.Communications biology · 2025Article
- Role of thalamus in human conscious perception revealed by low-intensity focused ultrasound neuromodulation.Nature communications · 2025Article
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Abstract
Research into the role of thalamocortical circuits in anesthesia-induced unconsciousness is difficult due to anatomical and functional complexity. Prior neuroimaging studies have examined either the thalamus as a whole or focused on specific subregions, overlooking the distinct neuronal subtypes like core and matrix cells. We conducted a study of heathy volunteers and functional magnetic resonance imaging during conscious baseline, deep sedation, and recovery. We advanced the functional gradient mapping technique to delineate the functional geometry of thalamocortical circuits, within a framework of the unimodal-transmodal functional axis of the cortex. Here we show a significant shift in this geometry during deep sedation, marked by a transmodal-deficient geometry. This alteration is closely linked to the spatial variations in the matrix cell composition within the thalamus. This research bridges cellular and systems-level understanding, highlighting the crucial role of thalamic core-matrix functional architecture in understanding the neural mechanisms of states of consciousness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.