Evidence map›Paper›PMID 39252120›Full record

ArticleAdvances in rheumatology (London, England)2024

Progranulin mediates the onset of pristane induced systemic lupus erythematosus.

Michun He, Aubryanna Hettinghouse, Yufei Bi, Yuehong Chen, Chuanju Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in rheumatology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michun HeDepartment of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003, USA. michunhe@suda.edu.cn.ORCID 0000-0001-6040-7775
Aubryanna HettinghouseDepartment of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003, USA.
Yufei BiDepartment of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003, USA.
Yuehong ChenDepartment of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003, USA.
Chuanju LiuDepartment of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003, USA.

Funding

The immunological mechanism of PGRNs anti-inflammatory effect - Renewal - 1R01AR062207 · NIAMS · YALE UNIVERSITY · PI Chuanju Liu · 2012 to 2026
$5.6M
NCATS NIH HHS R01AR062207NIAMS NIH HHS R01 AR062207
6 · The paper itself

Abstract

backgroundsProgranulin (PGRN) is a growth factor-like molecule with diverse roles in homeostatic and pathogenic processes including the control of immune and inflammatory responses. Pathogenic inflammation is a hallmark of systemic lupus erythematosus (SLE) and elevated serum levels of PGRN has been evaluated as a biomarker of disease activity in SLE. However, the role of PGRN in SLE has not been fully investigated. This study is aimed to determine the potential involvements of PGRN in SLE.

methodsWild type (WT) and PGRN knockout (PGRN

resultsFollowing exposure to pristane, PGRN

conclusionThe results indicate that PGRN participates in inflammatory response and renal damage in pristane induced SLE models, suggesting that PGRN mediates the onset of SLE.

Indexed as

Antibodies, AntinuclearDisease Models, AnimalImmunoglobulin GIntercellular Signaling Peptides and ProteinsLupus Erythematosus, SystemicMice, Inbred C57BLMice, KnockoutProgranulinsTerpenesAnimalsCollagenKidneyMiceSpleenAntibodies, AntinuclearCollagenGrn protein, mouseImmunoglobulin GIntercellular Signaling Peptides and ProteinspristaneProgranulinsTerpenesAnti-dsDNA antibodyInflammationProgranulinRenal lesionSystemic lupus erythematosus

Identifiers

PMID39252120
PMCPMC13488808

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.