Evidence map›Paper›PMID 39252477›Full record

ArticleInternational journal of stem cells2025

An Efficient Endothelial Cell Differentiation Protocol Using Bioactive Lipid O-Cyclic Phytosphingosine-1-Phosphate in Human Embryonic Stem Cells.

Ki-Sang Jo, Won-Jun Jo, Ainsley Mike Antao, Janardhan Keshav Karapurkar, Young Jun Park, Myeong-Jun Choi, Suresh Ramakrishna, Kye-Seong Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ki-Sang JoDepartment of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0009-0009-0775-7632
Won-Jun JoDepartment of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0009-0006-1442-3321
Ainsley Mike AntaoDepartment of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0002-9409-927X
Janardhan Keshav KarapurkarDepartment of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0002-0198-4035
Young Jun ParkR&D Center, Axceso Biopharma Co., Ltd., Yongin, Korea.ORCID https://orcid.org/0009-0009-9570-1574
Myeong-Jun ChoiR&D Center, Axceso Biopharma Co., Ltd., Yongin, Korea.ORCID https://orcid.org/0009-0004-5612-7809
Suresh RamakrishnaDepartment of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0002-4038-1085
Kye-Seong KimDepartment of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0001-5550-1660

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioactive lipids like sphingosine-1-phosphate (S1P) and lysophosphatidic acid have gained significant attention as signaling molecules with regulatory roles in stem cell proliferation and differentiation. The novel chemically synthesized sphingosine metabolite O-cyclic phytosphingosine-1-phosphate (cP1P) is derived from phytosphingosine-1-phosphate (P1P) and shares structural similarities with S1P. Previously, the role of cP1P in regulating ALK3/BMPR signaling during cardiomyocyte differentiation from human embryonic stem cells (hESCs) was demonstrated. In this study, the applicability of cP1P for endothelial cells (ECs) differentiation from hESCs was investigated an efficient method to obtain a high yield of functional ECs over several passages was standardized. The ECs derived from hESCs showed cellular and molecular characteristics similar to the native ECs. Thus, the results of this study open avenues for further research into cP1P-based stem cell differentiation for regenerative therapies.

Indexed as

Bioactive lipidsEndothelial cell differentiationEndothelial cell functionHuman embryonic stem cells

Identifiers

PMID39252477
PMCPMC12122251

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.