Evidence map›Paper›PMID 39252979›Full record

ArticleiScience2024

Serum lipidome associates with neuroimaging features in patients with traumatic brain injury.

Ilias Thomas, Virginia F J Newcombe, Alex M Dickens, Sophie Richter, Jussi P Posti, Andrew I R Maas, Olli Tenovuo, Tuulia Hyötyläinen, András Büki, David K Menon and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ilias ThomasSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Virginia F J NewcombeDivision of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK.
Alex M DickensTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Sophie RichterDivision of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK.
Jussi P PostiNeurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.
Andrew I R MaasDepartment of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium.
Olli TenovuoNeurocenter, Department of Neurology and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.
Tuulia HyötyläinenSchool of Science and Technology, Örebro University, Örebro, Sweden.
András BükiSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
David K MenonDivision of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK.
Matej OrešičSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
CENTER-TBI MR subgroup Participants and Investigators

Funding

Wellcome Trust
6 · The paper itself

Abstract

Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin in the brain. We investigated the relationship between traumatic microstructural changes in white matter from magnetic resonance imaging (MRI) and quantitative lipidomic changes from blood serum. The study cohort included 103 patients from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Diffusion tensor fitting generated fractional anisotropy (FA) and mean diffusivity (MD) maps for the MRI scans while ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry was applied to analyze the lipidome. Increasing severity of TBI was associated with higher MD and lower FA values, which scaled with different lipidomic signatures. There appears to be consistent patterns of lipid changes associating with the specific microstructure changes in the CNS white matter, but also regional specificity, suggesting that blood-based lipidomics may provide an insight into the underlying pathophysiology of TBI.

Indexed as

LipidomicsNeuroscienceSystems biology

Identifiers

PMID39252979
PMCPMC11381842

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.