Evidence map›Paper›PMID 39253204›Full record

ArticleHeliyon2024

The microenvironmental factors induced invasive tumor cells in glioblastoma.

Jianyu Zhang, Jinghui Li, Renli Qi, Shipeng Li, Xin Geng, Hong Shi, Hualin Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jianyu ZhangSecond Department of Neurosurgery, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan, China.
Jinghui LiSecond Department of Neurosurgery, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan, China.
Renli QiSecond Department of Neurosurgery, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan, China.
Shipeng LiSecond Department of Neurosurgery, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan, China.
Xin GengSecond Department of Neurosurgery, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan, China.
Hong ShiState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
Hualin YuSecond Department of Neurosurgery, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) cells have the potential to switch from being "proliferative cells" to peritumoral "invasive cells". Peritumoral GBM cells have highly invasive properties that allow them to survive surgery, leading to recurrence. The mechanisms underlying the manner in which the tumor microenvironment (TME) regulates the invasiveness of GBM remain unclear. Single-cell RNA sequencing analysis revealed heterogeneity in GBM cells, microglia and macrophages. In this study, the Oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) expression indicated higher invasiveness in core GBM cells. Under environmental stress, the expression of OSMR and LIFR were up-regulated with the effect of hypoxic, acidic, and low-glucose conditions

Indexed as

Intratumoral heterogeneitySingle cell RNA-seqTumor invasionTumor microenvironment

Identifiers

PMID39253204
PMCPMC11381606

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.