Evidence map›Paper›PMID 39253918›Full record

SynthesisCurrent topics in medicinal chemistry2024

Catalase: A Potential Pharmacologic Target for Hydrogen Peroxide in the Treatment of COVID-19.

Aleksandr Urakov, Natalya Urakova, Aleksey Reshetnikov, Aleksey Shklyaev, Vladimir Nikolenko, Anatoly Osipov, Natalya Klyachko, Yulia Sorokina, Nikita Muhutdinov, Sergey Okovityi and 1 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current topics in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aleksandr UrakovDepartment of General and Clinical Pharmacology, Izhevsk State Medical University, Izhevsk, Russia.ORCID 0000-0002-9829-9463
Natalya UrakovaDepartment of General and Clinical Pharmacology, Izhevsk State Medical University, Izhevsk, Russia.ORCID 0000-0002-4233-9550
Aleksey ReshetnikovDepartment of General and Clinical Pharmacology, Izhevsk State Medical University, Izhevsk, Russia.
Aleksey ShklyaevDepartment of Faculty Therapy with Courses in Endocrinology and Hematology, Izhevsk State Medical University, Izhevsk, Russia.
Vladimir NikolenkoDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow, Russia.
Anatoly OsipovDepartment of Medical Biophysics, Research Institute of Translational Medicine, N.I. Pirogov Russian Medical University, Moscow, Russia.
Natalya KlyachkoDepartment of Chemical Enzymology, Lomonosov Moscow State University, Moscow, Russia.
Yulia SorokinaDepartment of General and Clinical Pharmacology, Privolzhsky Research Medical University, Nizhniy Novgorod, Russia.
Nikita MuhutdinovDepartment of General and Clinical Pharmacology, Izhevsk State Medical University, Izhevsk, Russia.
Sergey OkovityiDepartment of Pharmacology and Clinical Pharmacology, Saint Petersburg Chemical Pharmaceutical University, Saint Petersburg, Russia.
Petr ShabanovDepartment of Neuropharmacology, Institute of Experimental Medicine, Saint Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute respiratory distress syndrome in the elderly with COVID-19 complicated by airway obstruction with sputum and mucus, and cases of asphyxia with blood, serous fluid, pus, or meconium in newborns and people of different ages can sometimes cause hypoxemia and death from hypoxic damage to brain cells, because the medical standard does not include intrapulmonary injections of oxygen-producing solutions. The physical-chemical repurposing of hydrogen peroxide from an antiseptic to an oxygen-producing antihypoxant offers hope for the development of new drugs.

methodsThis manuscript is a meta-analysis performed according to PRISMA guidelines.

resultsIt is shown that replacement of the traditional acidic activity of hydrogen peroxide solutions by alkaline activity with pH 8.4 and heating the solutions to the temperature of +37 - +42 °C allows to repurpose hydrogen peroxide from antiseptics into inhalation and intrapulmonary mucolytics, pyolytics and antihypoxants releasing oxygen. The fact is that warm alkaline hydrogen peroxide solution (WAHPS) in local interaction with sputum, mucus, pus, blood and meconium provides optimal conditions for the metabolism of hydrogen peroxide to oxygen gas under the action of the enzyme catalase, always present in these tissues. It was established that WAHPS liquefies these biological masses due to alkaline saponification of lipid and protein-lipid complexes and simultaneously transforms dense masses into soft oxygen foam due to active enzymatic metabolism of hydrogen peroxide to oxygen gas, the rapidly appearing bubbles of which are formed by the type of "cold boiling" and literally explode these masses. The results of the first experiments showed that inhalation and intrapulmonary injections of WAHPS can significantly optimize the treatment of suffocation and hypoxemia. DISCUSSION: The results showed that catalase, which is found in sputum, mucus, pus, and blood, may be a target for localized WAHPS because this enzyme provides an intensive metabolism of hydrogen peroxide to oxygen gas up to the formation of the cold boiling process.

conclusionThese data provide a new perspective way for intrapulmonary drugs and new technologies for the emergency increase of blood oxygenation through the lungs in asphyxia with thick sputum, mucus, pus, meconium and blood.

Indexed as

CatalaseCOVID-19 Drug TreatmentHydrogen PeroxideCOVID-19HumansSARS-CoV-2CatalaseHydrogen PeroxideCatalaseExpectorantsHemolyticsHydrogen peroxideHypoxia.Intra-pulmonaryMucolyticsOxygen-producing antihypoxantPyolyticsSuffocation

Identifiers

PMID39253918

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.