Evidence map›Paper›PMID 39254313›Full record

ArticleJournal of virology2024

Newcastle disease virus induces clathrin-mediated endocytosis to establish infection through the activation of PI3K/AKT signaling pathway by VEGFR2.

Lei Fan, Hongtao Xiao, Jinlian Ren, Yuechi Hou, Juncheng Cai, Wanyan Wu, Bin Xiang, Qiuyan Lin, Ming Liao, Tao Ren and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lei Fan *College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Hongtao Xiao *College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Jinlian Ren *College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Yuechi HouCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Juncheng CaiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Wanyan WuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Bin XiangCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.
Qiuyan LinCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Ming LiaoNational and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangzhou, China.ORCID 0000-0001-8731-4528
Tao RenCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.ORCID 0000-0002-5213-8736
Libin ChenCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.ORCID 0000-0002-7819-2810

Funding

China Postdoctoral Foundation Project | Postdoctoral Research Foundation of China (China Postdoctoral Research Foundation) GZC20230858Colleges Innovation Project of Guangdong 2023KJCX028MOE | Double First Class University Plan 2023B10564003MOST | National Key Research and Development Program of China (NKPs) 2023YFD1800604MOST | National Natural Science Foundation of China (NSFC) 32372981,32302842,31872492
6 · The paper itself

Abstract

The phosphatidyl-inositol 3-kinase/serine-threonine kinase (PI3K/ AKT) signaling pathway constitutes a classical phosphorylation cascade that integrates tyrosine, lipid, and serine acid-threonine phosphorylation, affecting cell function. The pathway is vulnerable to viral infection. Newcastle disease virus (NDV) poses a significant threat to the global poultry industry; however, its mechanism of early viral cell invasion and pathogenesis remain unclear. Previous IMPORTANCE: Newcastle disease virus (NDV) is a threat to the global poultry industry; however, the mechanisms of NDV infection remain unclear. NDV affects the phosphatidyl-inositol 3-kinase/serine-threonine kinase (PI3K/ AKT) signaling pathway, requiring endocytosis for successful infection. Based on previous studies, we identified a close correlation between NDV infection and replication and the PI3K/AKT signaling pathway activity. This study examined the molecular mechanisms through which NDV activates the PI3K/AKT signaling pathway to regulate endocytosis and facilitate infection. This study showed that early-stage

Indexed as

EndocytosisNewcastle DiseaseNewcastle disease virusPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionVascular Endothelial Growth Factor Receptor-2Virus ReplicationAnimalsCell LineChickensClathrinHumansPhosphorylationClathrinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktVascular Endothelial Growth Factor Receptor-2endocytosisNewcastle disease viruspathogenesisPI3K/AKT signaling pathway

Identifiers

PMID39254313
PMCPMC11494881

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.