ReviewSignal transduction and targeted therapy2024
Sex difference in human diseases: mechanistic insights and clinical implications.
Review in Signal transduction and targeted therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sex differences in multimorbidity: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Sex- and gender-specific differences in treatment efficacy and safety of traditional Chinese medicine: a scoping review.Frontiers in global women's health · 2026Pooled it
- Sex differences in the gut microbiome and related metabolites: role in cardiometabolic disease.Gut microbes · 2026Review
- Peak filling rate assessed by myocardial perfusion imaging predicts adverse outcomes in women with chronic coronary syndromes.Quantitative imaging in medicine and surgery · 2026Article
- A practical approach to illustrate the importance of the bodily energy and heat balances and of the associated regulatory loops to healthcare students.BMC medical education · 2026Article
- XYomics: detecting sex-dependent molecular mechanisms in omics data.Nucleic acids research · 2026Article
- Women's Special Issue Series: Biomedicines (2nd Edition).Biomedicines · 2026Article
- Activation of the G-protein coupled estrogen receptor 1 (GPER1) reduces transient receptor potential vanilloid 1 (TRPV1) activity and human iPSC-derived nociceptive neuron firing.Stem cell research & therapy · 2026Article
- Identifying genetic contributions of 6q21 loci and PPAR pathway to antipsychotic-induced metabolic syndrome: a Sex-Stratified Multi-Omics study.Molecular psychiatry · 2026Article
- X-Linked Intellectual Developmental Disorder-93 Caused by BRWD3 Mutation in Females: A Case Report and Literature Review.Molecular genetics & genomic medicine · 2026Review
- Age- and Sex-Specific Distribution of the Triglyceride-Glucose Index in a Large Chinese Population: Cross-Sectional Study.JMIR diabetes · 2026Article
- Association Between Extreme Climate Exposures and Bodily Pain: Evidence from the Chinese Health and Retirement Longitudinal Study.Journal of epidemiology and global health · 2026Article
- Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study.Acta neuropsychiatrica · 2026Review
- The Multifaceted Role of Androgen Receptor Signaling in Immunity: Implications for Oncology.Molecular cancer research : MCR · 2026Review
- Biologic sex and health differences, diabetes, metabolic syndrome, and cancer.Hormones (Athens, Greece) · 2026Article
- SASdb: a comprehensive database for sex-biased alternative splicing profiles in human tissues.Biology of sex differences · 2026Article
- Mechanism of hepatitis C virus-mediated development and progression of liver cirrhosis and hepatocellular carcinoma.World journal of gastroenterology · 2026Article
- Harnessing PDX and PDX 2.0: the next-generation paradigm for precision oncology and translational breakthroughs.Molecular cancer · 2026Review
- Redesigning medicine: integrating sex and gender for better health outcomes.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- An online non-radiographic osteoporosis prediction calculator constructed using interpretable machine learning.BioData mining · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Sex characteristics exhibit significant disparities in various human diseases, including prevalent cardiovascular diseases, cancers, metabolic disorders, autoimmune diseases, and neurodegenerative diseases. Risk profiles and pathological manifestations of these diseases exhibit notable variations between sexes. The underlying reasons for these sex disparities encompass multifactorial elements, such as physiology, genetics, and environment. Recent studies have shown that human body systems demonstrate sex-specific gene expression during critical developmental stages and gene editing processes. These genes, differentially expressed based on different sex, may be regulated by androgen or estrogen-responsive elements, thereby influencing the incidence and presentation of cardiovascular, oncological, metabolic, immune, and neurological diseases across sexes. However, despite the existence of sex differences in patients with human diseases, treatment guidelines predominantly rely on male data due to the underrepresentation of women in clinical trials. At present, there exists a substantial knowledge gap concerning sex-specific mechanisms and clinical treatments for diverse diseases. Therefore, this review aims to elucidate the advances of sex differences on human diseases by examining epidemiological factors, pathogenesis, and innovative progress of clinical treatments in accordance with the distinctive risk characteristics of each disease and provide a new theoretical and practical basis for further optimizing individualized treatment and improving patient prognosis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.