Evidence map›Paper›PMID 39256555›Full record

ArticleCommunications biology2024

Calcium modulates the tethering of BCOR-PRC1.1 enzymatic core to KDM2B via liquid-liquid phase separation.

Rui Chen, Feng Shen, Yulong Zhang, Mingze Sun, Yan Dong, Yue Yin, Chen Su, Chao Peng, Jinsong Liu, Jinxin Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rui Chen *Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
Feng Shen *Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
Yulong ZhangState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
Mingze SunState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
Yan DongState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
Yue YinNational Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai, 201210, China.ORCID 0000-0002-7693-3910
Chen SuNational Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai, 201210, China.
Chao PengNational Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai, 201210, China.ORCID 0000-0002-6814-2676
Jinsong LiuDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. liu_jinsong@gibh.ac.cn.ORCID 0000-0003-2317-0558
Jinxin XuState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. xu_jinxin@gibh.ac.cn.ORCID 0000-0002-1680-7533

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recruitment of non-canonical BCOR-PRC1.1 to non-methylated CpG islands via KDM2B plays a fundamental role in transcription control during developmental processes and cancer progression. However, the mechanism is still largely unknown on how this recruitment is regulated. Here, we unveiled the importance of the Poly-D/E regions within the linker of BCOR for its binding to KDM2B. Interestingly, we also demonstrated that these negatively charged Poly-D/E regions on BCOR play autoinhibitory roles in liquid-liquid phase separation (LLPS) of BCOR

Indexed as

CalciumJumonji Domain-Containing Histone DemethylasesPolycomb Repressive Complex 1Proto-Oncogene ProteinsRepressor ProteinsF-Box ProteinsHumansPhase SeparationProtein BindingBCOR protein, humanCalciumF-Box ProteinsJumonji Domain-Containing Histone DemethylasesKDM2A protein, humanPolycomb Repressive Complex 1Proto-Oncogene ProteinsRepressor Proteins

Identifiers

PMID39256555
PMCPMC11387744

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.